8.A.92.1.13
Dmx-like protein 2, DMXL2 or Rabconnectin-3, of 3036 aas. It is a component of intercellular desmosome junctions and plays a role in stratified epithelial integrity and cell-cell adhesion
by promoting desmosome assembly. It also functions as an effector in the
TP53-dependent apoptotic pathway. DMXL2, a gene encoding the rabconnectin-3α vesicular protein, is present in human subjects with mental retardation and neuroendocrine impairment
of reproduction (Wahab et al. 2017). Rabconnectin-3 complexes of higher eukaryotes regulate acidification of organelles such as lysosomes and endosomes by facilitating V-ATPase assembly (Jaskolka et al. 2021).
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| Accession Number: | Q8TDJ6 |
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| Protein Name: | DmX-like protein 2 |
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| Length: | 3036 |
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| Molecular Weight: | 339641.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 / Peripheral membrane protein2 |
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| Substrate |
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1: MHLHQVLTGA VNPGDNCYSV GSVGDVPFTA YGSGCDIVIL ANDFECVQII PGAKHGNIQV
61: SCVECSNQQG RIAASYGNAV CIFEPLGINS HKRNCQLKCQ WLKTGQFFLS SVTYNLAWDP
121: QDNRLLTATD SIQLWAPPGD DILEEEEEID NTVPPVLNDW KCVWQCKTSV SVHLMEWSPD
181: GEYFATAGKD DCLLKVWYPM TGWKSSIIPQ DHHEVKRRQS STQFSFVYLA HPRAVTGFSW
241: RKTSKYMPRG SVCNVLLTSC HDGVCRLWAE TLLPEDCLLG EQICETTTSS IASSLSHAGR
301: HKDRIQHALE TIHHLKNLRK GQRRSSVLVT HAELMPDQTA MHEVQRHISH HANALCHFHI
361: AASINPATDI PNVLVGTAFN VDDGNGGFVV HWLNNKEFHF TSSTEVFMHQ LRKLSDKQVD
421: HENDDADRED EEHSQEDRER GLHMKLDHDL SLDRESEAGT GSSEHEDGER EGSPRTYSRL
481: SVPMPLPTVL LDRKIETLLT EWNKNPDMLF TIHPVDGTFL VWHVKYLDEY NPGIFRQVQV
541: SFSSRIPVAF PSGDASSLSK NIMMYACINA TKDSHHTLLH QEGMSVGSPH GSQPHSRSHS
601: THMNILAPTV MMISKHIDGS LNQWAVTFAD KSAFTTVLTV SHKFRYCGHR FHLNDLACHS
661: VLPLLLTSSH HNALLTPELD CQWDSDNKLS RLMDPVKHIK GSSKQPLRNA ATRTFHDPNA
721: IYSELILWRV DPIGPLSYTG GVSELARINS LHTSAFSNVA WLPTLIPSYC LGTYCNSASA
781: CFVASDGKNL RLYQAVVDAR KLLDELSDPE SSKLIGEVFN IVSQQSTARP GCIIELDAIT
841: NQCGSNTQLL HVFQEDFIIG YKPHKEDMEK KETEIFFQPS QGYRPPPFSE KFFLVVIEKD
901: SNNNSILHMW HLHLKSVQAC LAKASEGASS ESLLSVPGQK NVDSSPETSP SVSPMPHSSS
961: IANLQTASKL ILSSRLVYSQ PLDLPESVEV IRATPSAGHL SSSSIYPVCL APYLVVTTCS
1021: DNKVRFWKCC MEANPECNKS DEKEIYHWKR WPLMNDEGED NSSTVSIVGR PVAVSCSYTG
1081: RLAVAYKQPI HHNGFVSKEF SMHVCIFECE STGGSEWVLE QTIHLDDLVK VGSVLDSRVS
1141: VDSNLFVYSK SDALLSKDRY LIPNIKHLVH LDWVSKEDGS HILTVGVGAN IFMYGRLSGI
1201: VTEQTNSKDG VAVITLPLGG SIKQGVKSRW VLLRSIDLVS SVDGTPSLPV SLSWVRDGIL
1261: VVGMDCEMHV YAQWKHAVKF GDTEADSSNA EEAAMQDHST FKSNMLARKS VVEGTAISDD
1321: VFCSPTVIQD GGLFEAAHVL SPTLPQYHPT QLLELMDLGK VRRAKAILSH LVKCIAGEVA
1381: IVRDPDAGEG TKRHLSRTIS VSGSTAKETV TVGKDGTRDY TEIDSIPPLP LYALLAADQD
1441: TSYRISEEST KIPQSYEDQT VSQPEDQYSE LFQIQDIPTD DIDLEPEKRE NKSKVINLSQ
1501: YGPAYFGQEH ARVLSSHLMH SSLPGLTRLE QMFLVALADT VATTSTELDE SRDKSCSGRD
1561: TLDECGLRYL LAMRLHTCLL TSLPPLYRVQ LLHQGVSTCH FAWAFHSEAE EELINMIPAI
1621: QRGDPQWSEL RAMGIGWWVR NINTLRRCIE KVAKASFQRN NDALDAALFY LSMKKKAVVW
1681: GLFRSQHDEK MTTFFSHNFN EDRWRKAALK NAFSLLGKQR FEQSAAFFLL AGSLKDAIEV
1741: CLEKMEDIQL AMVIARLYES EFETSSTYIS ILNQKILGCQ KDGSGFSCKR LHPDPFLRSL
1801: AYWVMKDYTR ALDTLLEQTP KEDDEHQVII KSCNPVAFSF YNYLRTHPLL IRRNLASPEG
1861: TLATLGLKTE KNFVDKINLI ERKLFFTTAN AHFKVGCPVL ALEVLSKIPK VTKTSALSAK
1921: KDQPDFISHR MDDVPSHSKA LSDGNGSSGI EWSNVTSSQY DWSQPIVKVD EEPLNLDWGE
1981: DHDSALDEEE DDAVGLVMKS TDAREKDKQS DQKASDPNML LTPQEEDDPE GDTEVDVIAE
2041: QLKFRACLKI LMTELRTLAT GYEVDGGKLR FQLYNWLEKE IAALHEICNH ESVIKEYSSK
2101: TYSKVESDLL DQEEMVDKPD IGSYERHQIE RRRLQAKREH AERRKSWLQK NQDLLRVFLS
2161: YCSLHGAQGG GLASVRMELK FLLQESQQET TVKQLQSPLP LPTTLPLLSA SIASTKTVIA
2221: NPVLYLNNHI HDILYTIVQM KTPPHPSIED VKVHTLHSLA ASLSASIYQA LCDSHSYSQT
2281: EGNQFTGMAY QGLLLSDRRR LRTESIEEHA TPNSSPAQWP GVSSLINLLS SAQDEDQPKL
2341: NILLCEAVVA VYLSLLIHAL ATNSSSELFR LAAHPLNNRM WAAVFGGGVK LVVKPRRQSE
2401: NISAPPVLSE DIDKHRRRFN MRMLVPGRPV KDATPPPVPA ERPSYKEKFI PPELSMWDYF
2461: VAKPFLPLSD SGVIYDSDES IHSDEEDDAF FSDTQIQEHQ DPNSYSWALL HLTMVKLALH
2521: NVKNFFPIAG LEFSELPVTS PLGIAVIKNL ENWEQILQEK MDQFEGPPPN YINTYPTDLS
2581: VGAGPAILRN KAMLEPENTP FKSRDSSAFP VKRLWHFLVK QEVLQETFIR YIFTKKRKQS
2641: EVEADLGYPG GKAKVIHKES DMIMAFSVNK ANCNEIVLAS THDVQELDVT SLLACQSYIW
2701: IGEEYDRESK SSDDVDYRGS TTTLYQPSAT SYSASQVHPP SSLPWLGTGQ TSTGASVLMK
2761: RNLHNVKRMT SHPVHQYYLT GAQDGSVRMF EWTRPQQLVC FRQAGNARVT RLYFNSQGNK
2821: CGVADGEGFL SIWQVNQTAS NPKPYMSWQC HSKATSDFAF ITSSSLVATS GHSNDNRNVC
2881: LWDTLISPGN SLIHGFTCHD HGATVLQYAP KQQLLISGGR KGHVCIFDIR QRQLIHTFQA
2941: HDSAIKALAL DPYEEYFTTG SAEGNIKVWR LTGHGLIHSF KSEHAKQSIF RNIGAGVMQI
3001: DIIQGNRLFS CGADGTLKTR VLPNAFNIPN RILDIL