8.A.92.1.19
RhoA GTPase of 193 aas.  A small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. It mainly associated with the  cell cytoskeleton; in  the active state it binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (Wei et al. 2013).  It regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (Stirling et al. 2009).  Differential regulation of Cx43 and Cx26 hemichannels and gap junction channels by RhoA GTPase and the actin cytoskeleton has been observed (Jara et al. 2024).