8.A.92.1.4
Receptor of activated protein C kinase 1 of 317 aas and 0 TMSs. Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. It is nvolved in PKC-dependent translocation of ADAM12 to the cell membrane and promotes ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. It is required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. It regulates internalization of the muscarinic receptor CHRM2 and promotes apoptosis by increasing oligomerization of BAX while disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. It inhibits TRPM6 channel activity and regulates cell surface expression of some GPCRs. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (Ikebuchi et al. 2009).