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| Accession Number: | P45697 |
| Protein Name: | BmK I aka BmK-M1 |
| Length: | 84 |
| Molecular Weight: | 9496.00 |
| Species: | Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) [34649] |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | |
Cross database links:
| Pfam: | PF00537 |
|---|---|
Gene Ontology
GO:0005576
C:extracellular region
GO:0019871
F:sodium channel inhibitor activity
GO:0006952
P:defense response
GO:0009405
P:pathogenesis
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References (10)[1] “The cDNA and genomic DNA sequences of a mammalian neurotoxin from the scorpion Buthus martensii Karsch.” Xiong Y.-M.et.al. 9248001 [2] “Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity.” Ji Y.-H.et.al. 8896191 [3] “Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom.” Goudet C.et.al. 11322948 [4] “Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.” Wang C.-G.et.al. 12705833 [5] “Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.” Sun Y.-M.et.al. 12692120 [6] “Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1.” Liu L.-H.et.al. 15677695 [7] “A series of bioactivity-variant neurotoxins from scorpion Buthus martensii Karsch: purification, crystallization and crystallographic analysis.” Li H.-M.et.al. 10089445 [8] “Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel.” He X.-L.et.al. 10493862 [9] “Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.” Guan R.-J.et.al. 15321715 [10] “Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.” Ye X.et.al. 16209876
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1: MNYLVMISFA LLLMTGVESV RDAYIAKPHN CVYECARNEY CNDLCTKNGA KSGYCQWVGK 61: YGNGCWCIEL PDNVPIRVPG KCHR