8.B.1.1.13
Scorpion toxin, Cn12 of 67 aas and four disulfide bridges. he NMR structure has been determined. It has a beta-toxin sequence but alpha-like physiological activity (del Río-Portilla et al. 2004). It binds voltage-independently at site-3
of sodium channels (Nav) to inhibit the inactivation of the activated
channels, thereby blocking neuronal transmission.
|
| Accession Number: | P63019 |
|---|
| Protein Name: | Alpha-toxin Cn12 |
|---|
| Length: | 67 |
|---|
| Molecular Weight: | 7148.00 |
|---|
| Species: | Centruroides noxius (Mexican scorpion) [6878] |
|---|
| Location1 / Topology2 / Orientation3: |
Secreted1 |
|---|
| Substrate |
|
|---|
1: RDGYPLASNG CKFGCSGLGE NNPTCNHVCE KKAGSDYGYC YAWTCYCEHV AEGTVLWGDS
61: GTGPCRS