| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.B.15.1.1 | Sea anemone Class 4 toxin, SHTX-1/SHTX-2 (targets K+ channels in synamptosomal membranes) | Eukaryota |
Metazoa, Cnidaria | SHTX-1 of Stichodactyla haddoni (P0C7W7) |
|
8.B.15.1.2 | Homostoxin-Hdu1a (peptide U-SHTX-Sdd1) of 29 aas | Eukaryota |
Metazoa, Cnidaria | Homostoxin of Homostichanthus duerdeni |
|
8.B.15.1.3 | Precursor protein UG (U-actitoxin-Ugr1c; U-AITX-Ugr1c; AnmTX Ugr) of 162 aas and 1 N-terminal TMS. Pi-AnmTX Ugr 9a-1: affects the ASIC3 channel
(ACCN3) and produces analgesic effects. It produces a reversible
inhibitory effect on both the transient and the sustained current of
human ASIC3 channels expressed in X. laevis oocytes. It completely blocks
the transient component (IC50=10 µM) and partially (48%) inhibits the amplitude of the sustained component (IC50=1.44 µM). Using in vivo tests in mice, it reverses inflammatory and acid-induced pain (Osmakov et al. 2013). The NMR structure is known (5LAH_A). | Eukaryota |
Metazoa, Cnidaria | UG of Urticina grebelnyi |
|
8.B.15.1.4 | Delta-atitoxin of 233 aas and 1 N-terminal TMS followed by 6 short repeat sequences. It inhibits voltage-gated Na+ channels. It and other sea urchin peptides can also modulate the functions of the TRPV1 and TRPA1 channels (Kolesova et al. 2023). | Eukaryota |
Metazoa, Cnidaria | Antheopsis maculata (Sea anemone) |