8.B.16.1.3
Hadrucalcin of 74 aas. A knottin. Activates both skeletal ryanodine receptors (RYR1) and
cardiac ryanodine receptors (RYR2) by inducing a long-lasting
subconductance state, rapidly permeating the external membrane of
cardiomyocytes and inducing calcium release from intracellular
stores. Acts synergistically with caffeine (Schwartz et al. 2009).
|
| Accession Number: | B8QG00 |
|---|
| Protein Name: | Hadrucalcin |
|---|
| Length: | 74 |
|---|
| Molecular Weight: | 8593.00 |
|---|
| Species: | Hadrurus gertschi (Scorpion) [380989] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Secreted1 |
|---|
| Substrate |
|
|---|
1: MKTSSLTIIF IAVIITIICL NIHDIEAREI EFNAGRVVRS EKDCIKHLQR CRENKDCCSK
61: KCSRRGTNPE KRCR