8.B.3.1.6
U24-Theraphotoxin-Cgla (U24-TRTx-Cg1a) or Jingzhaotoxin-27 (JZTx-27) of 79 aas and 1 N-terminal TMS. JZTx-27 traps the voltage sensor of NsVBa (TC# 1,A,1,14,8) in one of the deactivated states. In mammalian NaVs, JZTx-27 preferably inhibits the inactivation of NaV1.5 by targeting the fourth transmembrane domain. This peptide antagonist preferentially targets prokaryotic NaVs, but it stabilizes the NsVBa voltage sensor in the deactivated state (Tang et al. 2017).
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| Accession Number: | B1P1H2 |
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| Protein Name: | U24-theraphotoxin-Cg1a |
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| Length: | 79 |
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| Molecular Weight: | 9089.00 |
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| Species: | Chilobrachys guangxiensis (Chinese earth tiger tarantula) [278060] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MRVLFIIAVL ALISVGCYAS EMKDRSSRNE VLSAIFAIEE PQERDCLGLF WICNYMDDKC
61: CPGYKCERSS PWCKIDIWG