8.B.8.1.11
K+ channel toxin, α-KTx3.12 of Androctonus amoreuxi (African fattail scorpion; Scorpio amoreuxi) of 38 aas. It is a potent inhibitor of voltage-dependent potassium channels, with a preference for Kv1.3/KCNA3 versus Kv1.2/KCNA2 (Abbas et al. 2008). Members of this family can also form lethal sterol-dependent membrane pores called sterolysins (Place et al. 2024).
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| Accession Number: | P0C8R1 |
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| Protein Name: | Potassium channel toxin alpha-KTx 3.12 |
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| Length: | 38 |
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| Molecular Weight: | 4192.00 |
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| Species: | Androctonus amoreuxi (African fattail scorpion) [112024] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: GVEINVKCTG SHQCIKPCKD AGMRFGKCIN RKCHCTPK