9.A.1.3.1
Inositol polyphosphate 5-phosphatase, OCRL, of 910 aas. It catalyzes the hydrolysis of the 5-position phosphate of
phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and
phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the
greatest catalytic activity towards PtdIns(4,5)P2 (Kisseleva et al. 2000). It also acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote
phagosome closure, through attenuation of PI3K signaling (Bohdanowicz et al. 2012). Mutations in the encoding gene can give rise to Dent disease (Jiang et al. 2025).
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| Accession Number: | Q01968 |
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| Protein Name: | Inositol polyphosphate 5-phosphatase OCRL |
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| Length: | 901 |
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| Molecular Weight: | 104205.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 |
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| Substrate |
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1: MEPPLPVGAQ PLATVEGMEM KGPLREPCAL TLAQRNGQYE LIIQLHEKEQ HVQDIIPINS
61: HFRCVQEAEE TLLIDIASNS GCKIRVQGDW IRERRFEIPD EEHCLKFLSA VLAAQKAQSQ
121: LLVPEQKDSS SWYQKLDTKD KPSVFSGLLG FEDNFSSMNL DKKINSQNQP TGIHREPPPP
181: PFSVNKMLPR EKEASNKEQP KVTNTMRKLF VPNTQSGQRE GLIKHILAKR EKEYVNIQTF
241: RFFVGTWNVN GQSPDSGLEP WLNCDPNPPD IYCIGFQELD LSTEAFFYFE SVKEQEWSMA
301: VERGLHSKAK YKKVQLVRLV GMMLLIFARK DQCRYIRDIA TETVGTGIMG KMGNKGGVAV
361: RFVFHNTTFC IVNSHLAAHV EDFERRNQDY KDICARMSFV VPNQTLPQLN IMKHEVVIWL
421: GDLNYRLCMP DANEVKSLIN KKDLQRLLKF DQLNIQRTQK KAFVDFNEGE IKFIPTYKYD
481: SKTDRWDSSG KCRVPAWCDR ILWRGTNVNQ LNYRSHMELK TSDHKPVSAL FHIGVKVVDE
541: RRYRKVFEDS VRIMDRMEND FLPSLELSRR EFVFENVKFR QLQKEKFQIS NNGQVPCHFS
601: FIPKLNDSQY CKPWLRAEPF EGYLEPNETV DISLDVYVSK DSVTILNSGE DKIEDILVLH
661: LDRGKDYFLT ISGNYLPSCF GTSLEALCRM KRPIREVPVT KLIDLEEDSF LEKEKSLLQM
721: VPLDEGASER PLQVPKEIWL LVDHLFKYAC HQEDLFQTPG MQEELQQIID CLDTSIPETI
781: PGSNHSVAEA LLIFLEALPE PVICYELYQR CLDSAYDPRI CRQVISQLPR CHRNVFRYLM
841: AFLRELLKFS EYNSVNANMI ATLFTSLLLR PPPNLMARQT PSDRQRAIQF LLGFLLGSEE
901: D