Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.1.6
The ghrelin receptor, a peptide-activated (Growth hormone secretagogue) class A GPCR, GHS-R or GH-releasing peptide receptor (Mary et al., 2012). Intestinal dysmotility is associated with decreased ghrelin and vimentin expression and loss of intestinal cells of Cajal (Sukhotnik et al. 2021).

Accession Number:Q92847
Protein Name:Growth hormone secretagogue receptor type 1
Length:366
Molecular Weight:41329.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 2693   
Pfam: PF00001   
KEGG: hsa:2693   

Gene Ontology

GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0043005 C:neuron projection
GO:0005886 C:plasma membrane
GO:0001616 F:growth hormone secretagogue receptor activity
GO:0016520 F:growth hormone-releasing hormone receptor activity
GO:0017046 F:peptide hormone binding
GO:0008154 P:actin polymerization or depolymerization
GO:0008343 P:adult feeding behavior
GO:0032869 P:cellular response to insulin stimulus
GO:0046697 P:decidualization
GO:0030252 P:growth hormone secretion
GO:0009755 P:hormone-mediated signaling pathway
GO:0050728 P:negative regulation of inflammatory response
GO:0046676 P:negative regulation of insulin secretion
GO:0032691 P:negative regulation of interleukin-1 beta production
GO:0045409 P:negative regulation of interleukin-6 biosynthetic process
GO:0042536 P:negative regulation of tumor necrosis factor biosynthetic process
GO:0032100 P:positive regulation of appetite
GO:0045923 P:positive regulation of fatty acid metabolic process
GO:0043568 P:positive regulation of insulin-like growth factor receptor signaling pathway
GO:0040018 P:positive regulation of multicellular organism growth
GO:0043134 P:regulation of hindgut contraction
GO:0051963 P:regulation of synapse assembly
GO:0032094 P:response to food

References (6)

[1] “A receptor in pituitary and hypothalamus that functions in growth hormone release.”  Howard A.D.et.al.   8688086
[2] “Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.”  Petersenn S.et.al.   11356716
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Growth hormone secretagogue receptor family members and ligands.”  Smith R.G.et.al.   11322507
[5] “Ghrelin is a growth-hormone-releasing acylated peptide from stomach.”  Kojima M.et.al.   10604470
[6] “Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.”  Pantel J.et.al.   16511605
Structure:
6KO5     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG 
61:	NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ 
121:	FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV 
181:	LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW 
241:	RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI 
301:	SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT 
361:	ESSINT