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9.A.14.10.1
Gonadotropin-releasing hormone receptor

Accession Number:P30968
Protein Name:Gonadotropin-releasing hormone receptor
Length:328
Molecular Weight:37731.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P30968 P30968
eggNOG: NOG277514 NOG277514
HEGENOM: HBG506082 HBG506082
Entrez Gene ID: 2798   
Pfam: PF00001   
Drugbank: Drugbank Link   
KEGG: hsa:2798    hsa:2798   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004968 F:gonadotropin-releasing hormone receptor activity
GO:0007275 P:multicellular organismal development

References (34)

[1] “Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor.”  Kakar S.S.et.al.   1333190
[2] “Cloning and characterization of the human GnRH receptor.”  Chi L.et.al.   8386108
[3] “The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.”  Kakar S.S.et.al.   7534732
[4] “Molecular structure of the human gonadotropin-releasing hormone receptor gene.”  Kakar S.S.et.al.   9272108
[5] “Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor.”  Grosse R.et.al.   9259321
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene.”  Kottler M.L.et.al.   10366411
[8] “A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.”  de Roux N.et.al.   9371856
[9] “Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.”  Layman L.C.et.al.   9425890
[10] “The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred.”  de Roux N.et.al.   10022417
[11] “Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration.”  Caron P.et.al.   10084584
[12] “Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.”  Pralong F.P.et.al.   10523035
[13] “The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.”  Pitteloud N.et.al.   11397842
[14] “A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene.”  Soederlund D.et.al.   11318785
[15] “Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction.”  Costa E.M.F.et.al.   11397871
[16] “Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.”  Maya-Nunez G.et.al.   11994356
[17] “Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.”  Karges B.et.al.   12679486
[18] “Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor.”  Kakar S.S.et.al.   1333190
[19] “Cloning and characterization of the human GnRH receptor.”  Chi L.et.al.   8386108
[20] “The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.”  Kakar S.S.et.al.   7534732
[21] “Molecular structure of the human gonadotropin-releasing hormone receptor gene.”  Kakar S.S.et.al.   9272108
[22] “Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor.”  Grosse R.et.al.   9259321
[23] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[24] “Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene.”  Kottler M.L.et.al.   10366411
[25] “A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.”  de Roux N.et.al.   9371856
[26] “Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.”  Layman L.C.et.al.   9425890
[27] “The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred.”  de Roux N.et.al.   10022417
[28] “Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration.”  Caron P.et.al.   10084584
[29] “Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.”  Pralong F.P.et.al.   10523035
[30] “The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.”  Pitteloud N.et.al.   11397842
[31] “A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene.”  Soederlund D.et.al.   11318785
[32] “Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction.”  Costa E.M.F.et.al.   11397871
[33] “Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.”  Maya-Nunez G.et.al.   11994356
[34] “Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.”  Karges B.et.al.   12679486

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIRVT VTFFLFLLSA TFNASFLLKL 
61:	QKWTQKKEKG KKLSRMKLLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL 
121:	KLFSMYAPAF MMVVISLDRS LAITRPLALK SNSKVGQSMV GLAWILSSVF AGPQLYIFRM 
181:	IHLADSSGQT KVFSQCVTHC SFSQWWHQAF YNFFTFSCLF IIPLFIMLIC NAKIIFTLTR 
241:	VLHQDPHELQ LNQSKNNIPR ARLKTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRL 
301:	SDPVNHFFFL FAFLNPCFDP LIYGYFSL