9.A.14.13.10
The apelin hormone receptor (angiotensin receptor; GPCR APJ; GPCR HC11) of 380 aas. The human apelin (77 aas) receptor is coupled to G proteins that inhibit adenylate cyclase
activity.
It plays a role in various processes in adults such as
regulation of blood pressure, heart contractility, and heart failure.
During heart formation, it acts as a receptor for elabela hormone (ELA). It influences cell movement during embryonic development and serves as an alternative coreceptor with CD4 for HIV-1 infection (Pauli et al. 2014); it may also be involved in
the development of AIDS dementia. Elevated Na+ is a dynamic and reversible modulator of mitochondrial metabolism in the heart (Chung et al. 2024). The cardiac lipidome is also important to the progression of heart failure (Flori et al. 2025).
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| Accession Number: | P35414 |
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| Protein Name: | Apelin receptor |
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| Length: | 380 |
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| Molecular Weight: | 42660.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK
61: RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL
121: TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ
181: CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL
241: RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV
301: NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK
361: GGEQMHEKSI PYSQETLVVD