9.A.14.13.22
P2Y1 purinoceptor of 373 aas and 7 TMSs. Receptor for extracellular adenine
nucleotides such as ATP and ADP. In platelets binding to ADP leads to
mobilization of intracellular calcium ions via activation of
phospholipase C, a change in platelet shape, and probably to platelet
aggregation (Jin et al. 1998).
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| Accession Number: | P47900 |
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| Protein Name: | P2Y purinoceptor 1 |
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| Length: | 373 |
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| Molecular Weight: | 42072.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ FYYLPAVYIL
61: VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG
121: DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV
181: VAISPILFYS GTGVRKNKTI TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI
241: VRALIYKDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
301: RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEDMTLN
361: ILPEFKQNGD TSL