9.A.14.16.2
Frizzled-2, Fe2 of 694 aas and 7 TMSs. Receptor for Wnt proteins. Most frizzled
receptors are coupled to the beta-catenin canonical signaling pathway,
which leads to the activation of disheveled proteins, inhibition of
GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt
target genes. A second signaling pathway involving PKC and calcium
fluxes has been seen for some family members, but it is not yet clear if
it represents a distinct pathway or can be integrated in the
canonical pathway, as PKC seems to be required for Wnt-mediated
inactivation of GSK-3 kinase. Both pathways seem to involve interactions
with G-proteins. Required to coordinate the cytoskeletons of epidermal
cells to produce a parallel array of cuticular hairs and bristles (Hsieh et al. 1999).
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| Accession Number: | Q9VVX3 |
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| Protein Name: | Frizzled-2 |
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| Length: | 694 |
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| Molecular Weight: | 75451.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MRHNRLKVLI LGLVLLLTSC RADGPLHSAD HGMGGMGMGG HGLDASPAPG YGVPVIPKDP
61: NLRCEEITIP MCRGIGYNMT SFPNEMNHET QDEAGLEVHQ FWPLVEIKCS PDLKFFLCSM
121: YTPICLEDYH KPLPVCRSVC ERARSGCAPI MQQYSFEWPE RMACEHLPLH GDPDNLCMEQ
181: PSYTEAGSGG SSGGSGGSGS GSGSGGKRKQ GGSGSGGSGA GGSSGSTSTK PCRGRNSKNC
241: QNPQGEKASG KECSCSCRSP LIFLGKEQLL QQQSQMPMMH HPHHWYMNLT VQRIAGVPNC
301: GIPCKGPFFS NDEKDFAGLW IALWSGLCFC STLMTLTTFI IDTERFKYPE RPIVFLSACY
361: FMVAVGYLSR NFLQNEEIAC DGLLLRESST GPHSCTLVFL LTYFFGMASS IWWVILSFTW
421: FLAAGLKWGN EAITKHSQYF HLAAWLIPTV QSVAVLLLSA VDGDPILGIC YVGNLNPDHL
481: KTFVLAPLFV YLVIGTTFLM AGFVSLFRIR SVIKQQGGVG AGVKADKLEK LMIRIGIFSV
541: LYTVPATIVI GCYLYEAAYF EDWIKALACP CAQVKGPGKK PLYSVLMLKY FMALAVGITS
601: GVWIWSGKTL ESWRRFWRRL LGAPDRTGAN QALIKQRPPI PHPYAGSGMG MPVGSAAGSL
661: LATPYTQAGG ASVASTSHHH LHHHVLKQPA ASHV