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9.A.14.2.4
ACTH-specific receptor, MC2R, in the melanocortin receptor family that includes MC1R - MC5R which recognize different melanocortin peptides.  Domains responsible for specific membrane transport and lignad specificity in MC2R have been identified (Fridmanis et al. 2010). MC accessory protein (MRAP) facilitates MC2 receptor trafficking and allows properly localized receptor to bind ACTH and consequently signal (Sebag and Hinkle 2009).

Accession Number:Q01718
Protein Name:Adrenocorticotropic hormone receptor
Length:297
Molecular Weight:33927.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKHIINSYEN INNTARNNSD CPRVVLPEEI FFTISIVGVL ENLIVLLAVF KNKNLQAPMY 
61:	FFICSLAISD MLGSLYKILE NILIILRNMG YLKPRGSFET TADDIIDSLF VLSLLGSIFS 
121:	LSVIAADRYI TIFHALRYHS IVTMRRTVVV LTVIWTFCTG TGITMVIFSH HVPTVITFTS 
181:	LFPLMLVFIL CLYVHMFLLA RSHTRKISTL PRANMKGAIT LTILLGVFIF CWAPFVLHVL 
241:	LMTFCPSNPY CACYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKKM IFCSRYW