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9.A.14.2.6
Cannabinoid receptor 2, CNR2. The endocannabinoid system is widely present in the retina where it can modulate neurotransmitter release and ion channel activity (Bouchard et al. 2016). Endogenous endocannabinoids such as anandamide and 2-arachidonoyl glycerol (2AG) bind to the receptor and influence many processes including feeding, learning, memory, pain, emotions, sleep and dreams (Murillo-Rodriguez et al. 2017).  It plays a vital role in regulation of immune response, inflammation, pain, and other metabolic processes. Its 3-d structure has been studied by NMR (Yeliseev and Gawrisch 2017). EPR studies revealed that higher mobility was observed in the center of internal loop 3,  and a structural change occurs between agonist vs. inverse agonist-bound CB2 in the extracellular tip of transmembrane helix 6 (Yeliseev et al. 2021).

Accession Number:P34972
Protein Name:Cannabinoid receptor 2
Length:360
Molecular Weight:39681.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Structure:
2KI9   5ZTY   6KPC   6KPF   6PT0     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 
61:	SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 
121:	VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 
181:	ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 
241:	VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 
301:	LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC