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9.A.14.3.18 5-Hydroxytryptamine (serotonin) receptor 4, HTR4, of 338 aas and 7 TMSs. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. The tmAC/PKA/CatSper channel signals via the 5-HT4 receptor, and after sAC and PKA are activated by such stimulation, sperm hyperactivation is enhanced (Sakamoto et al. 2021).
Accession Number:	Q13639
Protein Name:	5-hydroxytryptamine receptor 4
Length:	388
Molecular Weight:	43761.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 
61:	SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 
121:	AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 
181:	STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 
241:	QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 
301:	GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD 
361:	AVECGGQWES QCHPPATSPL VAAQPSDT

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