9.A.14.3.6
The serotonin or 5-hydroxytrytamine (5-HT) G protein-coupled receptor, 5HT1B. Wang et al (2013) reported the crystal
structures of the human 5-HT1B bound to the
agonist antimigraine medications ergotamine and dihydroergotamine. The
structures revealed similar binding modes for these ligands, which occupy
the orthosteric pocket and an extended binding pocket close to the
extracellular loops. The orthosteric pocket is formed by residues
conserved in the 5-HT receptor family.
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| Accession Number: | P28222 |
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| Protein Name: | 5-hydroxytryptamine receptor 1B |
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| Length: | 390 |
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| Molecular Weight: | 43568.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT
61: LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV
121: VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI
181: SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL
241: KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE
301: KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL
361: NSLINPIIYT MSNEDFKQAF HKLIRFKCTS