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9.A.14.4.1
Calcitonin receptor 

Accession Number:P30988
Protein Name:Calcitonin receptor
Length:490
Molecular Weight:57303.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 799   
Pfam: PF00002    PF02793   
KEGG: hsa:799   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0032841 F:calcitonin binding
GO:0004948 F:calcitonin receptor activity
GO:0005515 F:protein binding
GO:0008565 F:protein transporter activity
GO:0007189 P:activation of adenylate cyclase activity by G-protein signaling pathway
GO:0007204 P:elevation of cytosolic calcium ion concentration
GO:0045762 P:positive regulation of adenylate cyclase activity
GO:0072659 P:protein localization in plasma membrane
GO:0031623 P:receptor internalization
GO:0051384 P:response to glucocorticoid stimulus

References (14)

[1] “Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.”  Gorn A.H.et.al.   1331173
[2] “Cloning and characterization of an abundant subtype of the human calcitonin receptor.”  Kuestner R.E.et.al.   8078488
[3] “Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.”  Albrandt K.et.al.   7588285
[4] “An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid.”  Frendo J.L.et.al.   8143880
[5] “A novel calcitonin receptor gene in human osteoclasts from normal bone marrow.”  Nishikawa T.et.al.   10570950
[6] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang Z.et.al.   15340161
[9] “Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor.”  Nussenzveig D.R.et.al.   7720653
[10] “A new type of human calcitonin receptor isoform generated by alternative splicing.”  Nakamura M.et.al.   7733946
[11] “Identification of a novel family of G protein-coupled receptor associated sorting proteins.”  Simonin F.et.al.   15086532
[12] “Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women.”  Masi L.et.al.   9675109
[13] “Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women.”  Masi L.et.al.   9571205
[14] “Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.”  Taboulet J.et.al.   9817931
Structure:
5II0   5UZ7   6NIY   6PFO   6PGQ     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ 
61:	QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK 
121:	HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRKLTTIF 
181:	PLNWKYRKAL SLGCQRVTLH KNMFLTYILN SMIIIIHLVE VVPNGELVRR DPVSCKILHF 
241:	FHQYMMACNY FWMLCEGIYL HTLIVVAVFT EKQRLRWYYL LGWGFPLVPT TIHAITRAVY 
301:	FNDNCWLSVE THLLYIIHGP VMAALVVNFF FLLNIVRVLV TKMRETHEAE SHMYLKAVKA 
361:	TMILVPLLGI QFVVFPWRPS NKMLGKIYDY VMHSLIHFQG FFVATIYCFC NNEVQTTVKR 
421:	QWAQFKIQWN QRWGRRPSNR SARAAAAAAE AGDIPIYICH QEPRNEPANN QGEESAEIIP 
481:	LNIIEQESSA