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9.A.14.4.12
Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor). It is involved in the regulation of vascular tone and the modulatioin of inflammatory and metabolic responses (Hendrikse et al. 2019). The high resoution 3-d structure is known, revealing its mechanism of receptor activation, including the conformational dynamics that occur upon agonist binding (Josephs et al. 2021).

Accession Number:Q16602
Protein Name:Calcitonin gene-related peptide type 1 receptor
Length:461
Molecular Weight:52929.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q16602
eggNOG: NOG255868
DIP: DIP-37674N
Entrez Gene ID: 10203   
Pfam: PF00002    PF02793   
KEGG: hsa:10203   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005768 C:endosome
GO:0005887 C:integral to plasma membrane
GO:0005764 C:lysosome
GO:0001605 F:adrenomedullin receptor activity
GO:0001635 F:calcitonin gene-related polypeptide receptor activity
GO:0004948 F:calcitonin receptor activity
GO:0008565 F:protein transporter activity
GO:0007189 P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0001525 P:angiogenesis
GO:0006816 P:calcium ion transport
GO:0006171 P:cAMP biosynthetic process
GO:0071329 P:cellular response to sucrose stimulus
GO:0007187 P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007507 P:heart development
GO:0050728 P:negative regulation of inflammatory response
GO:0030819 P:positive regulation of cAMP biosynthetic process
GO:0048661 P:positive regulation of smooth muscle cell proliferation
GO:0031623 P:receptor internalization
GO:0006937 P:regulation of muscle contraction

References (7)

[1] “A cDNA encoding the calcitonin gene-related peptide type 1 receptor.”  Aiyar N.et.al.   8626685
[2] “A human orphan calcitonin receptor-like structure.”  Fluehmann B.et.al.   7818539
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang Z.et.al.   15340161
[6] “Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.”  ter Haar E.et.al.   20826335
[7] “Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.”  Kusano S.et.al.   22102369
Structure:
3AQF   3N7P   3N7R   3N7S   4RWF   4RWG   5V6Y   6D1U   6E3Y   6UMG   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA 
61:	EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT 
121:	WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL 
181:	FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 
241:	IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 
301:	ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI 
361:	AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS 
421:	YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N