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9.A.14.4.8
Pituitary adenylate cyclase (AC)-activating polypeptide type 1 receptor of 468 aas and 7 TMSs. Aenylate cyclase 8E (AC8E) is a trunked form of adenylate cyclase in mammals that prevents the translocation of other ACs towards the plasma membrane, further reducing the cAMP responsiveness to extracellular signals. his dual inhibitory mechanism provides an additional level of regulation of cAMP-dependent signals integration (Legueux-Cajgfinger et al. 2023).

Accession Number:P41586
Protein Name:Pituitary adenylate cyclase-activating polypeptide type I receptor
Length:468
Molecular Weight:53314.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 117   
Pfam: PF00002    PF02793   
KEGG: hsa:117   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004999 F:vasoactive intestinal polypeptide receptor activity
GO:0007190 P:activation of adenylate cyclase activity
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0048011 P:nerve growth factor receptor signaling pathway
GO:0007283 P:spermatogenesis

References (4)

[1] “Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.”  Ogi K.et.al.   7902709
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7.”  Stoffel M.et.al.   7851900
[4] “Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.”  Sun C.et.al.   17470806
Structure:
2JOD   3N94   6LPB   6M1H   6M1I   6P9Y     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
61:	ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
121:	DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
181:	LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
241:	YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
301:	DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 
361:	LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 
421:	NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT