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9.A.18.1.1
Microcin uptake permease, SbmA, of 406 aas and 7 or 8 TMSs. It may function as a peptide uptake porter. The biofilm environment favors rapid evolution of resistance and provides new insights into the dynamic evolution of antibiotic resistance (Usui et al. 2023). For example, mutations in sbmA occur with high frequency in biofilms, but not in the planktonic state.

Accession Number:P0AFY6
Protein Name:Protein SbmA aka B0377
Length:406
Molecular Weight:46459.00
Species:Escherichia coli [83333]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate peptide, microcin

Cross database links:

RefSeq: AP_001028.1    NP_414911.1   
Entrez Gene ID: 946884   
Pfam: PF05992   
BioCyc: EcoCyc:SBMA-MONOMER    ECOL168927:B0377-MONOMER   
KEGG: ecj:JW0368    eco:b0377   

Gene Ontology

GO:0009276 C:Gram-negative-bacterium-type cell wall
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12.”  Lavina M.et.al.   3543211
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFKSFFPKPG TFFLSAFVWA LIAVIFWQAG GGDWVARITG ASGQIPISAA RFWSLDFLIF 
61:	YAYYIVCVGL FALFWFIYSP HRWQYWSILG TALIIFVTWF LVEVGVAVNA WYAPFYDLIQ 
121:	TALSSPHKVT IEQFYREVGV FLGIALIAVV ISVLNNFFVS HYVFRWRTAM NEYYMANWQQ 
181:	LRHIEGAAQR VQEDTMRFAS TLENMGVSFI NAIMTLIAFL PVLVTLSAHV PELPIIGHIP 
241:	YGLVIAAIVW SLMGTGLLAV VGIKLPGLEF KNQRVEAAYR KELVYGEDDA TRATPPTVRE 
301:	LFSAVRKNYF RLYFHYMYFN IARILYLQVD NVFGLFLLFP SIVAGTITLG LMTQITNVFG 
361:	QVRGAFQYLI NSWTTLVELM SIYKRLRSFE HELDGDKIQE VTHTLS