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9.A.39.1.3
Iron-regulated surface determinant, IsdA (IsdA binds transferrin, heme, hemoglobin, hemin, fetuin, asialo fetuin, protein A, fibronectin and fibrinogen) (Liu et al., 2008). The pathway for uptake of heme from human methemoglobin by the iron-regulated surface determinants (Isd) is: B (9.A.39.1.1)→ A (9.A.39.1.3) → C (9.A.39.1.4) → E (3.A.1.14.18)→ DF (3.A.1.14.18) → cytoplasm (Zhu et al., 2008).

Accession Number:P0C1S5
Protein Name:IsdA
Length:354
Molecular Weight:39133.00
Species:Staphylococcus aureus [1280]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate ferroheme b

Cross database links:

Pfam: PF00746    PF05031   

Gene Ontology

GO:0009986 C:cell surface
GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0046872 F:metal ion binding

References (6)

[1] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[2] “Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.”  Park R.-Y.et.al.   15880095
[3] “Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.”  Clarke S.R.et.al.   16544250
[4] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[5] “Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.”  Park R.-Y.et.al.   15880095
[6] “Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.”  Clarke S.R.et.al.   16544250

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTKHYLNSKY QSEQRSSAMK KITMGTASII LGSLVYIGAD SQQVNAATEA TNATNNQSTQ 
61:	VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN 
121:	ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI 
181:	PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS 
241:	EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ 
301:	NEVHKQGPSK DSKAKELPKT GLTSVDNFIS TVAFATLALL GSLSLLLFKR KESK