9.A.43.1.1
Cd2+ tolerance factor, TaTM20, a hydrophobic polypeptide of 889 amino acids, containing 20 transmembrane domains arranged as a 5-fold internal repeating unit of 4 transmembrane domains each (Kim et al., 2008). The 4 TMS repeat has been referred to as the pfam13962 or PGG domain. The PGG domain is named for the conserved sequence motif found at the start of the domain.The protein appears to function as a Cd2+ exporter, possibly using the pmf and functioning as a secondary carrier (see family description).
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| Accession Number: | Q2MJU2 |
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| Protein Name: | Cd2+ tolerance factor |
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| Length: | 889 |
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| Molecular Weight: | 97723.00 |
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| Species: | Triticum aestivum (Wheat) [4565] |
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| Number of TMSs: | 20 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cadmium(2+) |
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[1] “Expression of the novel wheat gene TM20 confers enhanced cadmium tolerance to bakers' yeast.” Kim Y.Y. et.al. 18411273
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1: MECGGVSAVQ VQPAVHMGQP GQPAKPPVQP WEYSLRKYLL LLAALVVTVT YAAGFSPPGG
61: VWQAAHDGQP AGDPIIRGTH YRRYLAFFYC NATAFAASLV VIVLILILAV RHDKKGKDSR
121: WVVVPLRLVM VLDLLSLMGA YGAGTCQDKI SIVYSAVLVA AVFLYVAVLK MMDWWCPDNK
181: TGPGCDGTMS SAPNSNSNSG DVMSTPDPDS DAVTIPSPLR DSDPNVKEEE DRKREALKKL
241: KANERLRKVL MLLATFAVSI TYVAGLSMPG GFWDSTGTSY RPGDAILKDR HRPRLTAFLL
301: CNTTSFVASL LIIMLLIIDG KKLRDKKARS LVLYGFIVVA LVSLVGAYTA GSCRETKTTI
361: YVVSLTGGIL AMAYILLYAF YTLKSSRSSP TQPTDALQQT TDNVSARKGL DKARSLVLLL
421: ATLAATITYT AGLDPPGGLW QDKGDGYIAG DPILITTNIR RYRAFYYCNS VAFVASLLVI
481: VLVQTERLIK HHVLEAAMIL DLFGLIGAYA AGSCRNVNSS VYVMALAGAA LIYVVIHIVF
541: FTLELDQKDK KDDDQEDELL EKRRKRLLLF AILAATITYQ AGLTPPGGFL LQDDTLGHHA
601: GDPILLHNYP VRYHAFFYCN SVSFMLSIAL IILLVNPNLY RPAIQSNALS VCTAVGLFCL
661: MGAYAAGSTQ HRKTSIYIFV LVAVVLLVAA GLLLVFLLKR KLSNAVVSPP REQNEEERKE
721: VEEKNEDEEE AKKHARRKYL MLLGILVASV AYQAGLEPPG GAWQNNDNGY EAGNPVMNDN
781: RRPRYLTFFY SNSVSFVASI VVIIMLLPQW LPKKKEGEWE KWSLRVMNWM IRLDLFALLV
841: AYAAGSNRGL KTSLYVVALI FAVLGYFAIH TVLACTVCRH ERRQSSSVV