TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.46.1.1
Tetraspanning Clarin-1, CLRN1 (USH3A gene).  The causative protein which when mutated, gives rise to human Usher syndrome type 3A (Phillips et al. 2013), blind-deafness (Reiners et al. 2006).  It exists in the USH complex involved in mechano-transduction in auditory hair cells and phooreceptors (Zallocchi et al. 2009; Ogun and Zallocchi 2014).

Accession Number:P58418
Protein Name:Clarin-1
Length:232
Molecular Weight:25719.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MPSQQKKIIF CMAGVFSFAC ALGVVTALGT PLWIKATVLC KTGALLVNAS GQELDKFMGE 
61:	MQYGLFHGEG VRQCGLGARP FRFSFFPDLL KAIPVSIHVN VILFSAILIV LTMVGTAFFM 
121:	YNAFGKPFET LHGPLGLYLL SFISGSCGCL VMILFASEVK IHHLSEKIAN YKEGTYVYKT 
181:	QSEKYTTSFW VIFFCFFVHF LNGLLIRLAG FQFPFAKSKD AETTNVAADL MY