9.A.49.1.2
Prenylated Rab acceptor protein 2 (PRAF2; JM4) of 178 aas and 4 TMSs in a 2 + 2 TMS arrangement. Its expression profiles and characteristics have been described (Fo et al. 2006; Koomoa et al. 2008). JM4 interacts with the CC chemokine receptor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV); CCR5 mutants lacking the carboxy (C)-terminus interfere with HIV infection (Schweneker et al. 2005). JM4, JWA (TC# 9.A.49.1.3), and GTRAP3-18 co-localise and heterodimerise indicating a functional relationship. JM4 co-localizes with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi. JM4 and GTRAP3-18 harbor a Rab-acceptor motif, indicating a function in vesicle formation in the Golgi. The cinokex may function in trafficking and membrane localization of CCR5 receptor, and possibly other receptors or amino acid transporters (Schweneker et al. 2005).  It may be involved in ER/Golgi transport and vesicular traffic, and it plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (Geerts et al. 2007). It is involved in  control of CCR5 cell-surface targeting (Da Silva et al. 2023).