9.A.49.1.3
PRAF3 of 188 aas and 4 TMSs.  It is also called PRA2, GTRAP3-18, JWA, ARL6IP5, DERP11, and Ar16-IP5. JWA, like JM4 (TC# 9.A.49.1.2), is a four TMS protein, which binds to the CCR5 receptor (Schweneker et al. 2005). JM4, JWA, and GTRAP3-18 co-localize and heterodimerize, indicating a functional relationship. JM4 co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi. JM4 and GTRAP3-18 harbor a Rab-acceptor motif, indicating a function in vesicle formation in the Golgi complex.Thus, Schweneker et al. 2005 demonstrated CCR5-interacting proteins, suggesting a function in trafficking and membrane localization of the receptor, possibly as well as other receptors and amino acid transporters.