TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
9.A.55.1.1 | The cisplatin (Pt2+ coordinatioin complex/ Pt2+ drug complexes) exporter, TMEM205; DUF4149. Genetic polymorphisms may alter chemotheraputic responses in lung cancer patients. (Shen et al., 2010; Shen and Gottesman 2012; Wang et al. 2014). The N- and C-termini may be extracellular (Attwood et al. 2016). Human TMEM205 mediates Pt(ii)-drug export selectively towards cisplatin and oxaliplatin but not carboplatin (Gallenito et al. 2020). By mutational analyses, they showed that hTMEM205 recognizes and allows Pt(ii)-extrusion by a putative sulfur-based translocation mechanism, thereby resulting in pre-target resistance. The small endosomal recycling GTPase, RAB8, plays a role in TMEM205-associated resistance to the chemotherapeutic drug cisplatin (Shen and Gottesman 2012). Cisplatin binding to the angiogenin protein provides a new molecular pathway and target for the drug's anticancer activity (Ferraro et al. 2023). | Eukaryota |
Metazoa, Chordata | TMEM205 of Homo sapiens (Q6UW68) |
9.A.55.1.2 | Uncharacterized protein of 171 aas and 4 TMSs | Bacteria |
Thermodesulfobacteriota | UP of Desulfobulbus propionicus |
9.A.55.1.3 | DUF4149 protein of 155 aas and 4 TMSs | Bacteria |
Pseudomonadota | DUF4149 protein Ralstonia pickettii |
9.A.55.1.4 | Uncharacterized protein of 295 aas and 5 or 6 TMSs in a 2 + 2 + 1 TMS arrangement, possibly with another TMS towards the C-terminus of the 110 aa N-terminal hydrophilic alanine-rich domain. | Eukaryota |
Viridiplantae, Chlorophyta | UP of Chlamydomonas reinhardtii (Chlamydomonas smithii) |
9.A.55.1.5 | Uncharacterized protein of 167 aas and 4 TMSs. | Bacteria |
Aquificota | UP of Sulfurihydrogenibium azorense |
9.A.55.1.6 | Uncharacterized protein of 179 aas and 4 TMSs. | Bacteria |
Nitrospirota | UP of Leptospirillum ferrodiazotrophum |
9.A.55.1.7 | Uncharacterized protein of 170 aas and 4 TMSs. | Bacteria |
Verrucomicrobiota | UP of Pedosphaera parvula |
9.A.55.1.8 | Uncharacterized protein of 158 aas and 4 TMSs. | Bacteria |
Armatimonadota | UP of Chthonomonas calidirosea |
9.A.55.1.9 | Uncharacterized DUF4149 protein of 147 aas and 4 TMSs. | Bacteria |
Bacteroidota | UP of Psychroflexus gondwanensis |
9.A.55.1.10 | Uncharacterized protein of 125 aas and 4 TMSs. | Bacteria |
Bdellovibrionota | UP of Bdellovibrio bacteriovorus |
9.A.55.1.11 | Uncharacterized protein of 167 aas and 4 TMSs | Bacteria |
Acidobacteriota | UP of Granulicella mallensis |
9.A.55.1.12 | Uncharacterized protein of 135 aas and 4 TMSs | Bacteria |
Pseudomonadota | UP of Glaciecola nitratireducens |
9.A.55.1.13 | Uncharacterized protein of 165 aas and 4 TMSs | Bacteria |
Pseudomonadota | UP of Halorhodospira halophila (Ectothiorhodospira halophila) |
9.A.55.1.14 | Uncharacterized protein of 143 aas and 4 TMSs | Bacteria |
Bacillota | UP of Sulfobacillus acidophilus |
9.A.55.2.1 | Uncharacterized protein of 186 aas and 4 TMSs | Eukaryota |
Fungi, Ascomycota | UP of Leptosphaeria maculans (Blackleg fungus) (Phoma lingam) |
9.A.55.2.2 | Uncharacterized protein of 208 aas and 4 TMSs. | Eukaryota |
Fungi, Basidiomycota | UP of Wallemia sebi |
9.A.55.3.1 | Uncharacterized protein of 169 aas and 4 TMSs. | Bacteria |
Cyanobacteriota | UP of Coleofasciculus chthonoplastes |