TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.A.55.1.1









The cisplatin (Pt2+ coordinatioin complex/ Pt2+ drug complexes) exporter, TMEM205; DUF4149. Genetic polymorphisms may alter chemotheraputic responses in lung cancer patients. (Shen et al., 2010; Shen and Gottesman 2012; Wang et al. 2014).  The N- and C-termini may be extracellular (Attwood et al. 2016). Human TMEM205 mediates Pt(ii)-drug export selectively towards cisplatin and oxaliplatin but not carboplatin (Gallenito et al. 2020). By mutational analyses, they showed that hTMEM205 recognizes and allows Pt(ii)-extrusion by a putative sulfur-based translocation mechanism, thereby resulting in pre-target resistance. The small endosomal recycling GTPase, RAB8, plays a role in TMEM205-associated resistance to the chemotherapeutic drug cisplatin (Shen and Gottesman 2012). Cisplatin binding to the angiogenin protein provides a new molecular pathway and target for the drug's anticancer activity (Ferraro et al. 2023).

Eukaryota
Metazoa, Chordata
TMEM205 of Homo sapiens (Q6UW68)
9.A.55.1.2









Uncharacterized protein of 171 aas and 4 TMSs

Bacteria
Thermodesulfobacteriota
UP of Desulfobulbus propionicus
9.A.55.1.3









DUF4149 protein of 155 aas and 4 TMSs

Bacteria
Pseudomonadota
DUF4149 protein Ralstonia pickettii
9.A.55.1.4









Uncharacterized protein of 295 aas and 5 or 6 TMSs in a 2 + 2 + 1 TMS arrangement, possibly with another TMS towards the C-terminus of the 110 aa N-terminal hydrophilic alanine-rich domain.

Eukaryota
Viridiplantae, Chlorophyta
UP of Chlamydomonas reinhardtii (Chlamydomonas smithii)
9.A.55.1.5









Uncharacterized protein of 167 aas and 4 TMSs.

Bacteria
Aquificota
UP of Sulfurihydrogenibium azorense
9.A.55.1.6









Uncharacterized protein of 179 aas and 4 TMSs.

Bacteria
Nitrospirota
UP of Leptospirillum ferrodiazotrophum
9.A.55.1.7









Uncharacterized protein of 170 aas and 4 TMSs.

Bacteria
Verrucomicrobiota
UP of Pedosphaera parvula
9.A.55.1.8









Uncharacterized protein of 158 aas and 4 TMSs.

Bacteria
Armatimonadota
UP of Chthonomonas calidirosea
9.A.55.1.9









Uncharacterized DUF4149 protein of 147 aas and 4 TMSs.

Bacteria
Bacteroidota
UP of Psychroflexus gondwanensis
9.A.55.1.10









Uncharacterized protein of 125 aas and 4 TMSs.

Bacteria
Bdellovibrionota
UP of Bdellovibrio bacteriovorus
9.A.55.1.11









Uncharacterized protein of 167 aas and 4 TMSs

Bacteria
Acidobacteriota
UP of Granulicella mallensis
9.A.55.1.12









Uncharacterized protein of 135 aas and 4 TMSs

Bacteria
Pseudomonadota
UP of Glaciecola nitratireducens
9.A.55.1.13









Uncharacterized protein of 165 aas and 4 TMSs

Bacteria
Pseudomonadota
UP of Halorhodospira halophila (Ectothiorhodospira halophila)
9.A.55.1.14









Uncharacterized protein of 143 aas and 4 TMSs

Bacteria
Bacillota
UP of Sulfobacillus acidophilus
9.A.55.2.1









Uncharacterized protein of 186 aas and 4 TMSs

Eukaryota
Fungi, Ascomycota
UP of Leptosphaeria maculans (Blackleg fungus) (Phoma lingam)
9.A.55.2.2









Uncharacterized protein of 208 aas and 4 TMSs.

Eukaryota
Fungi, Basidiomycota
UP of Wallemia sebi
9.A.55.3.1









Uncharacterized protein of 169 aas and 4 TMSs.

Bacteria
Cyanobacteriota
UP of Coleofasciculus chthonoplastes