9.A.57.1.8
Synaptotagmin-like protein 4, SYTL4, of 671 aas. It modulates exocytosis of dense-core granules and
secretion of hormones in the pancreas and the pituitary. It also interacts with
vesicles containing negatively charged phospholipids in a Ca2+-independent manner (Izumi et al. 2007). Mutations give rise to high functioning autism (Rafi et al. 2019).
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| Accession Number: | Q96C24 |
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| Protein Name: | Synaptotagmin-like protein 4 |
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| Length: | 671 |
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| Molecular Weight: | 76024.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Peripheral membrane protein2 |
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| Substrate |
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1: MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD
61: RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY
121: DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE TVGQSLLHQT QMGDIWPGRK IIQERQKEPS
181: VLFEVPKLKS GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE
241: TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL
301: NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD FGNIFVTGRI
361: AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY LLPDKSRQGK RKTSIKRDTI
421: NPLYDETLRY EIPESLLAQR TLQFSVWHHG RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL
481: HGKISAESPT GLPSHKGELV VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA
541: AKAGGTSDSF VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT
601: VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP GSWAEGTLQL
661: RSSMAKQKLG L