9.A.63.1.3
Sortlin, SORT1 of 831 aas and 2 TMSs, N- and C-terminal (Coutinho et al. 2012). Functions as a sorting receptor in the
Golgi compartment and as a clearance receptor on the cell surface.
Required for protein transport from the Golgi apparatus to the lysosomes
by a pathway that is independent of the mannose-6-phosphate receptor
(M6PR; LIMP2; TC# 9.B.39.1.8). Probably required in adipocytes for the
formation of specialized storage vesicles containing the glucose
transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs) (Bogan 2012). These
vesicles provide a stable pool of SLC2A4 and confer increased
responsiveness to insulin (Huang et al. 2013). May also mediate transport from the
endoplasmic reticulum to the Golgi (Bogan 2012).
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| Accession Number: | Q99523 |
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| Protein Name: | Sortilin |
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| Length: | 831 |
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| Molecular Weight: | 92068.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MERPWGAADG LSRWPHGLGL LLLLQLLPPS TLSQDRLDAP PPPAAPLPRW SGPIGVSWGL
61: RAAAAGGAFP RGGRWRRSAP GEDEECGRVR DFVAKLANNT HQHVFDDLRG SVSLSWVGDS
121: TGVILVLTTF HVPLVIMTFG QSKLYRSEDY GKNFKDITDL INNTFIRTEF GMAIGPENSG
181: KVVLTAEVSG GSRGGRIFRS SDFAKNFVQT DLPFHPLTQM MYSPQNSDYL LALSTENGLW
241: VSKNFGGKWE EIHKAVCLAK WGSDNTIFFT TYANGSCKAD LGALELWRTS DLGKSFKTIG
301: VKIYSFGLGG RFLFASVMAD KDTTRRIHVS TDQGDTWSMA QLPSVGQEQF YSILAANDDM
361: VFMHVDEPGD TGFGTIFTSD DRGIVYSKSL DRHLYTTTGG ETDFTNVTSL RGVYITSVLS
421: EDNSIQTMIT FDQGGRWTHL RKPENSECDA TAKNKNECSL HIHASYSISQ KLNVPMAPLS
481: EPNAVGIVIA HGSVGDAISV MVPDVYISDD GGYSWTKMLE GPHYYTILDS GGIIVAIEHS
541: SRPINVIKFS TDEGQCWQTY TFTRDPIYFT GLASEPGARS MNISIWGFTE SFLTSQWVSY
601: TIDFKDILER NCEEKDYTIW LAHSTDPEDY EDGCILGYKE QFLRLRKSSV CQNGRDYVVT
661: KQPSICLCSL EDFLCDFGYY RPENDSKCVE QPELKGHDLE FCLYGREEHL TTNGYRKIPG
721: DKCQGGVNPV REVKDLKKKC TSNFLSPEKQ NSKSNSVPII LAIVGLMLVT VVAGVLIVKK
781: YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL E