9.A.8.1.12
Iron transporter, FeoB, of 751 aas and 9 putative TMSs with a C-terminal GTPase domain. Plays a key role in iron uptake and virulence. The crystal structure of the N-terminal cytosolic domain (NFeoB) is known (Petermann et al. 2010). The strucuture reveals a monomeric protein comprised of two separate
sub-domains with GTPase and guanine-nucleotide dissociation inhibitor (GDI) functions, respectively. The GDI domain was found to display a novel fold, whereas the GTPase domain resembled that of known G
domains. The crystalized protein was in the rarely observed nucleotide-free state.
|
| Accession Number: | Q5X1N2 |
|---|
| Protein Name: | Ferrous iron transport protein B |
|---|
| Length: | 751 |
|---|
| Molecular Weight: | 82528.00 |
|---|
| Species: | Legionella pneumophila (strain Paris) [297246] |
|---|
| Number of TMSs: | 9 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
iron(2+) |
|---|
1: MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI EITDLPGVYS
61: LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL YLTSQLFELG KPVVVALNMM
121: DIAEHRGISI DTEKLESLLG CSVIPIQAHK NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ
181: QILNDLENQL ISKGYKNSFA YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD
241: ARYQKIHEIV TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF
301: QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV IAAMFFFLSL
361: LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP AIMAARTLDS ERDRLLTVMM
421: SPFMSCSARL AIYAVFVAAF FPSGGHNVVF SLYLIGILMA VFTGYILRKT TLKGHASPLI
481: LELPAYHRPS LRRLLRETSL RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD
541: SLLSIIGQWI TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEIAAA
601: HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR FDGAVGAYAY
661: LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYTT SVVFYQGAKF LDHPQQSMIW
721: ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN T