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9.A.8.1.12
Iron transporter, FeoB, of 751 aas and 9 putative TMSs with a C-terminal GTPase domain.  Plays a key role in iron uptake and virulence.  The crystal structure of the N-terminal cytosolic domain (NFeoB) is known (Petermann et al. 2010).  The strucuture  reveals a monomeric protein comprised of two separate sub-domains with GTPase and guanine-nucleotide dissociation inhibitor (GDI) functions, respectively. The GDI domain was found to display a novel fold, whereas the GTPase domain resembled that of known G domains. The crystalized protein was in the rarely observed nucleotide-free state.

Accession Number:Q5X1N2
Protein Name:Ferrous iron transport protein B
Length:751
Molecular Weight:82528.00
Species:Legionella pneumophila (strain Paris) [297246]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate ferrous iron ions

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI EITDLPGVYS 
61:	LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL YLTSQLFELG KPVVVALNMM 
121:	DIAEHRGISI DTEKLESLLG CSVIPIQAHK NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ 
181:	QILNDLENQL ISKGYKNSFA YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD 
241:	ARYQKIHEIV TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF 
301:	QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV IAAMFFFLSL 
361:	LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP AIMAARTLDS ERDRLLTVMM 
421:	SPFMSCSARL AIYAVFVAAF FPSGGHNVVF SLYLIGILMA VFTGYILRKT TLKGHASPLI 
481:	LELPAYHRPS LRRLLRETSL RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD 
541:	SLLSIIGQWI TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEIAAA 
601:	HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR FDGAVGAYAY 
661:	LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYTT SVVFYQGAKF LDHPQQSMIW 
721:	ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN T