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9.A.8.1.4
Ferrous iron uptake system, FeoB (Louvel et al., 2005)

Accession Number:Q5XPH7
Protein Name:Ferrous iron transport protein B
Length:690
Molecular Weight:77649.00
Species:Leptospira biflexa serovar Patoc. [456481]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Fe2+

Cross database links:

HEGENOM: HBG731320
RefSeq: YP_001838280.1   
Entrez Gene ID: 6220966   
Pfam: PF07664    PF02421    PF07670   
KEGG: lbi:LEPBI_I0879   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015093 F:ferrous iron transmembrane transporter acti...
GO:0005525 F:GTP binding
GO:0001882 F:nucleoside binding
GO:0015684 P:ferrous iron transport

References (2)

[1] “Isolation and characterization of FecA- and FeoB-mediated iron acquisition systems of the spirochete Leptospira biflexa by random insertional mutagenesis.”  Louvel H.et.al.   15838052
[2] “Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis.”  Picardeau M.et.al.   18270594

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKEKNIYLVG NPNCGKTTLF NQLTGLNQKT GNFSGVTVEK KEGVVYLPNL ELKITDLPGT 
61:	YGLGGIAEDK KIAYEVLLKR KENEVVIYVL DALNLERGLQ FLLQIIDMGV PTLVVLTMKD 
121:	VLEKKRIQLD LKKLKHSLGL EIVLVNAKSG EGISELKTLL SKEESYRKQK RLWTWGSKEE 
181:	SFLTSLKQKL KITTNEAEFF LSQALKFLNH DPHLQDSRYL NQFPNETKQF LTKELESKPL 
241:	QFAYQEEMIH RSILIKKIIS ETIHYPIAIQ GSWEERLDRI FLHPILGFVC FFLLMGLLFQ 
301:	SLFSFAEIPM DLIEEGITGL QETIGNVLSD GPLKSLLIEG ILGGVGSVVV FVPQIALLFL 
361:	FIGILEESGY LARASFLMDR LMGKFGLSGK SFIPLLSSAA CAVPAILGTR TIENKSDRFT 
421:	TIMVSPLIMC SARYPVYILI VGTVFSYPPI FGIFNVQGFV LFSMFFLGMI VSFTFALIFR 
481:	KTVFKENASY FVMELPRYNL PSFKSLFFTV YGKVKSFLAT AGQIILYISV ILWFLSHFPA 
541:	EYKDNVWKTS PIETSYIGRV GKVMEPAIEP LGFDWKIGIS ILTSFAAREV MVSTLAVLYG 
601:	SEEEGEESES LRETLRADKK PDGSPVWTPL TGLSLLLFFA FASQCMSTLA VTKKETGSLL 
661:	WPTVQFLYMT TLAIFTSFLV FQLGKILGFV