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9.B.104.2.1
Rhomboid protease (355 aas; 7TMSs)

Accession Number:P20350
Protein Name:Protein rhomboid
Length:355
Molecular Weight:39330.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 38168   
Pfam: PF01694   
KEGG: dme:Dmel_CG1004   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0007409 P:axonogenesis
GO:0048149 P:behavioral response to ethanol
GO:0007420 P:brain development
GO:0046845 P:branched duct epithelial cell fate determination, open tracheal system
GO:0016337 P:cell-cell adhesion
GO:0000910 P:cytokinesis
GO:0035225 P:determination of genital disc primordium
GO:0007174 P:epidermal growth factor catabolic process
GO:0007173 P:epidermal growth factor receptor signaling pathway
GO:0008586 P:imaginal disc-derived wing vein morphogenesis
GO:0007474 P:imaginal disc-derived wing vein specification
GO:0007479 P:leg disc proximal/distal pattern formation
GO:0035160 P:maintenance of epithelial integrity, open tracheal system
GO:0001763 P:morphogenesis of a branching structure
GO:0007438 P:oenocyte development
GO:0008355 P:olfactory learning
GO:0030707 P:ovarian follicle cell development
GO:0007422 P:peripheral nervous system development
GO:0045742 P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0006508 P:proteolysis
GO:0007176 P:regulation of epidermal growth factor receptor activity
GO:0007432 P:salivary gland boundary specification
GO:0035202 P:tracheal pit formation in open tracheal system
GO:0035311 P:wing cell fate specification

References (5)

[1] “Rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.”  Bier E.et.al.   2110920
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases.”  Urban S.et.al.   11672525
[5] “Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.”  Zettl M.et.al.   21439629

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MENLTQNVNE TKVDLGQEKE KEASQEEEHA TAAKETIIDI PAACSSSSNS SSYDTDCSTA 
61:	SSTCCTRQGE HIYMQREAIP ATPLPESEDI GLLKYVHRQH WPWFILVISI IEIAIFAYDR 
121:	YTMPAQNFGL PVPIPSDSVL VYRPDRRLQV WRFFSYMFLH ANWFHLGFNI VIQLFFGIPL 
181:	EVMHGTARIG VIYMAGVFAG SLGTSVVDSE VFLVGASGGV YALLAAHLAN ITLNYAHMKS 
241:	ASTQLGSVVI FVSCDLGYAL YTQYFDGSAF AKGPQVSYIA HLTGALAGLT IGFLVLKNFG 
301:	HREYEQLIWW LALGVYCAFT VFAIVFNLIN TVTAQLMEEQ GEVITQHLLH DLGVS