9.B.113.1.3
Transport and Golgi organization protein, TANGO, of 1430 aas and probably 3 TMSs, one N-terminal and two in the middle of the protein. It is required for protein secretion (Bard et al. 2006) and may participate in cargo loading by binding to COPII coat subunits and
guiding SH3-bound proteins into a growing carrier (Bard et al. 2006).
At basal transitional ER sites in follicle epithelial cells, it mediates
the exit of basal membrane proteins such as Vkg, LanB1 and Trol, from the
endoplasmic reticulum (ER) to basal Golgi clusters (Lerner et al. 2013). Homologues may exist in all eukaryotes and function in similar capacities (Elliott et al. 2020; Saito and Maeda 2019).
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| Accession Number: | Q9VMA7 |
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| Protein Name: | Transport and Golgi organization protein 1 |
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| Length: | 1430 |
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| Molecular Weight: | 159052.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
protein |
|---|
1: MRLTNEKATM QPQLSDLALV LGLLICCLPT LTWAATLSDK RLCADPKCEQ IISMGIAKIT
61: YAIGGEGLIS FKINSPIRVL SKSAGSNMQL WGVDINGRRG YANKDFIMEK KILVRDKDLL
121: YEVPVVGPGS PVQSVETPVQ SVETTVQPVL NASESTDDLA TTTTSPLEIA VDSIVVEHDK
181: LQDQQVPDPT AASKAQVQVI EGTELPLEAI AATTEGSIVP ETAADPQEAT NLDSTVVDTK
241: EPQALNSEAI KLQEEPKAQQ PATEAEKPPP LPQAINAELE DADDFDYGDD ETDDDSQQGS
301: QDNESIVEIA NDNKSINESI ELKPLSVAQL KKTDKVEDSK DETKEKHAEM EVSKQEDSSL
361: PTETLNVTAL EEQIDQKEFP KQVLDAAVEL KSSDPLPVEE VTETVAEPPR TIVEDKINEE
421: IVPVSAKIQA KPATVNPTEP IVAQSDAEIK APSESVISST TPAPVVEEAP QKADPVGLPP
481: LFEKKNFENP NNYYKQLQEE QEKQRLVAEA EEQKRLQEEA DQQKRLQEEA ALNKRLLEEA
541: EQQKRLQEEA EQQKRLQEEA ELNKRLLEEA EKQKRLHEES EQLQRSSEEA EPQLSVQEAN
601: MQQLNDSVDS QSNEIVDNNN RQQPEQYQQH HHHTESAFNH PSTASHTTPT PDAESPYAAV
661: QEETTEASQT DNHREGVGYV EPVALPATAS PVSEVPIKED AAGFGLFATI VDTVNNFIGK
721: DPQSDPADSS DELHRILYPG RPEVPPSQRK AEDFAPADVD GYCARFQAKD EHCHRSISLD
781: NFVEVMADKL VDHSQLLLCV VIAAISSLFF MFAYYCFCNS SQEGALLSKL NHLERSLLAS
841: HKENLIIKHD LMTTRTKLAS IEDNSFGSND MVADLKKQLE SELYEKAKLQ EQVGSLERDL
901: DNAAEAGLEL NKMLSEVLNG QNGDEAFMST VDELQRQLND QEKIIIEINN SLAEKSRENS
961: ELQYTFTEAT TRLNSELKTL QEDNYELEME KSKLQTRLQE IQAETESELA KALEARNYEM
1021: QKLQNQIVEL TVKWEREHGD LQTSLAKIEA LEDCLKAVGK DAIHNVQELI TSAKTRGELN
1081: AVHKKLVELQ SKVEQEEAHK QRLESQLQQS SQDVEQLKQD FNQSERDKLE AQTRLEVLSG
1141: YFREKENDLK KELSLQETKW LQHQGENAST VETQTLMKNE IQTLKSQNDE LRAEIEAQIA
1201: SHKAQMGTLE NRAHESWLAA RQSERRCEEA LAEAASLRRK LTTMASGGGG VGGDPGVMEA
1261: IAANGTSVLG AELKTAPSPL PLPGSPLLNM PNPLPFLAAP FSPFMGLPPP FLPPTGAGGA
1321: RPPPLGRMRS PPPSSRGDRD RERYSDYSDY DDYDDDEEDD RGMDRRRRHS GSWGRRHRGS
1381: YSHSPRTYRS LSPSDSRYNY NDTETDFSPP PSPPPVPSGR SATSRPYSEV