9.B.119.1.6
1,3-beta-D-glucan synthase, GFGLS2, of 1713 aas and 10 TMSs in a 4 (residues 390 - 510) + 4 (residues 560 - 700) + 4 (residues 1190 - 1360) + 4 (residues 1440 - 1570) + 1 (resdue 1630) + 1 (residue 1690). The biochemical, 3D structural characterization and potential catalytic mechanism of this membrane-bound beta-1, 3-glucan synthase, GFGLS2 from cultured mycelia of G. frondosa was investigated and provides a reasonably full picture of beta-1, 3-glucan synthesis in fungi (Yang et al. 2023).
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| Accession Number: | QIR82081.1 |
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| Protein Name: | QIR82081.1 1,3-beta-D-glucan synthase [Grifola frondosa] |
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| Length: | 1714 |
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| Molecular Weight: | |
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| Species: | Grifola frondosa [5627] |
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| Number of TMSs: | 18 |
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| Substrate |
UDP-D-glucose |
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1: MASNPGYGQP NPLNPFAAQQ PYGQPYGQPL RQYSNDSDGD SYMSRNASSV PLASAPYYDG
61: QYTPQSVGED AALNDYDRHY SASVDSHMST ATSILPSNPF SDMPNSCEPF PAWSAERQIP
121: MSTEEIEDIF LDLAQKFGFQ KDSMRNMFDF LMTLLDSRAS RMTPNQALLT VHADYIGGQH
181: ANYRKWYFAA QLNLDDAVGQ SQNPGLQRLR SVSGGGVKTA GTKSLDSALN RWRNAMNNMS
241: QYDRLRQVAL YLLCWGEAGN VRFTPECLCF IFKCADDYYR SPECQNRVDP VPEGLYLETV
301: IKPLYRFMRD QGYEVVEGKF VRRERDHEKI IGYDDINQLF WYPEGLAKIV LQDNRFTKFG
361: RIAWNRVFFK TFFEKRSAAH LLVNFNRIWI LHIAVFWFYT AYFSPKVYAP HNQQNPSAPM
421: TWSASALGGA VATLIMIFAT MAEFSYIPTT WNNASHLTTR LIFLLVVLAL TGGPTVYIAI
481: VDGRPGQGNI PLIVGIVQFF VSVVATLTFG LIPSGRMFGD RVAGKSRKYM ASQTFTASYP
541: ELKRTQRIAS IGLWMLIFGC KFTESYFFLT SSFSSPIAVM ARTKVQGCND KYFGTALCSN
601: QVPFALAIMY VMDLVLFFLD TYLWYIIWVV VFSVARSFHL GLSIWTPWKE VYTRMPKRIY
661: AKLLATAEME VKYKPKVLVS QVWNAIIISI EFFPLGGEAE RRISFFASSL TTALPEPLPV
721: DAMPTFTVLV PHYSEKILLS LREIIREEDQ NTRVTLLEYL KQLHPVEWDN FVKDTKILAE
781: ESETVTQFDG TATTNEKPGS KRTDDLPFYC IGFKTAAPEY TLRTRIWASL RAQTLYRTVS
841: GMMNYAKAIK LLYRVENPQI VQRFAGNTDR LERELERMSR RKFKFAVSMQ RYAKFNKEEL
901: ENAEFLLRAY PDLQIAYLDE EPGPKGSDPR LFSVLIDGHS ELDETTGKRK PKFRVELPGN
961: PILGDGKSDN QNHAIIFYRG EFLQLIDANQ DNYLEECIKI RNILGEFEQY SLSSQSPYAQ
1021: WGHKEFSKAP VAIVGTREYI FSENIGILGD IAAGKEQTFG TMTPRVLAWI GGKLHYGHPD
1081: FLNATFMTTR GGVSKAQKGL HLNEDIFAGM NAIGRGGRIK HSEYYQCGKG RDLGFGTILN
1141: FQTKLGTGMG EQMLSREYYY LGTQLPIDRF LTFYYGHPGF HINNILVIYS IQIFMITLLY
1201: LGTLNKQLAI CKVDTTGNVI GGQPGCYNLI PVFDWIKHCI VSIFLVFFIA FLPLFMQELL
1261: ERGTGKALIR LGKHFLSLSP IFEVFSTQIY SQSIQSNLTF GGARYIATGR GFATTRISFT
1321: ILYSRFAGPS IYMGMRNLLL LLYATMAIWT PYLIYFWISV CSLCIAPFVF NPHQFSFADY
1381: IIDYREFLRW MSRGNSRTKA SSWYGYCRLS RTMITGYKKK KLGHPSEKLS GDVPRASWRS
1441: VLFAEVIWPI CVATIFVIAY MFVKSFPDPN GRQNPSPLIR IAVIAVGPVV WNAAVLLSLF
1501: FISLFLGPML ESWTKFASVV AAFAHFLALI GLVAFFEFFW FLELWDASHA VLGVIAIIAI
1561: QRAIQKFLIS VFLSREYKHD ETNRAWWSGK WYGRGLGTSA LSQPAREFVV KIVEMSLWTS
1621: DFLLAHILLI VMAVPMFIPF VDKLHSTMMF WLRPSKQIRP PLFSTKQKRQ RRWIVLKYTF
1681: VYVVVVAFLA ALIVLPALFR DHITLHCTVC QNI