9.B.128 The O-antigen Polymerase, WzyE (WzyE) Family
The WzyX translocase (2.A.66.2.12) (an isoprenoid lipid sugar glucan flippase) forms a complex with Wzy (WzyE) and Wzz for assembly of periplasmic O-antigen in lipopolysaccharide (Marolda et al., 2006). WzyE (450aas; 11-13 TMSs) is referred to as the enterobacterial common antigen (ECA) polysaccharide chain elongation polymerase (Kajimura et al., 2005). However, it and its homologues 'look like' a permease and show appreciable sequence similarity with MFS and MATE carriers following TC BLAST searches. This family may be distantly related to 9.B.67, also designated as an O-antigen polymerase family.
This family belongs to the: O-Antigen Polymerase (OAPol) Superfamily.
References associated with 9.B.128 family:
Kajimura, J., A. Rahman, and P.D. Rick. (2005). Assembly of cyclic enterobacterial common antigen in Escherichia coli K-12. J. Bacteriol. 187: 6917-6927. 16199561
Luo, F., X. Sun, Z. Qu, and X. Zhang. (2016). Salmonella typhimurium-induced M1 macrophage polarization is dependent on the bacterial O antigen. World J Microbiol Biotechnol 32: 22. 26745982
Marolda, C.L., L.D. Tatar, C. Alaimo, M. Aebi, and M.A. Valvano. (2006). Interplay of the Wzx translocase and the corresponding polymerase and chain length regulator proteins in the translocation and periplasmic assembly of lipopolysaccharide o antigen. J. Bacteriol. 188: 5124-5135. 16816184