TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.129.1.1









Megalencephalic leukoencephalopathy with subcortical cysts 1 homologue, MLC1. May interact with several ion and water channels and cause channelopathies (Brignone et al. 2015). The disease is a progressive cerebral white matter disease in children caused by mutations in the MLC1 gene. This disease is histopathologically characterized by myelin splitting and intramyelinic vacuole formation. MLC1 is mainly expressed in the brain and leukocytes. MLC1 contains an even number (probably 8) TMSs and is expressed in distal astroglial processes in perivascular, subependymal, and subpial regions, possibly suggesting a role in transport across the blood-brain and brain-cerebrospinal fluid barriers. Astrocytes are of fundamental importance in maintaining the structural and functional integrity of neural tissue (Boor et al. 2005). GlialCAM/MLC1 may form a functional unit (Pérez-Rius et al. 2019).  Disturbed astrocyte regulation of ion and water homeostasis in MLC causes hyperexcitability of neuronal networks and seizures, suggesting a role for astrocytes in volume regulation in epilepsy (Dubey et al. 2018). Depolarization causes the formation of a ternary complex between GlialCAM, MLC1 and ClC-2 in astrocytes (Sirisi et al. 2017). MLC1 depends on the fluid mosaic membrane which has been reviewed (Nicolson and Ferreira de Mattos 2022).

 

Eukaryota
Metazoa, Chordata
MLC1 of Homo sapiens (Q15049)
9.B.129.1.2









MLC1 homolog of 414 aas and 6 or 7 TMSs.

Eukaryota
Metazoa, Chordata
MLC1 homolog of Liparis tanakae
9.B.129.1.3









Uncharacterized protein of 310 aas and 5 or 6 TMSs in a 1 or 2 + 4  TMS arrangement.

Eukaryota
Metazoa, Chordata
UP of Cyprinus carpio
9.B.129.1.4









Uncharaacterized protein of 307 aas and 6 TMSs.

Eukaryota
Metazoa, Chordata
UP of Takifugu flavidus