9.B.149.2.1
Regulator of σW transmembrane metaloprotease, RasP (YluC) of 422 aas and 4 - 6 TMSs. RasP, when defective, causes defects in
competence development, protein secretion and membrane protein
production (Zweers et al. 2012). σV activation in B. subtilis is controlled by regulated intramembrane proteolysis and requires RasP (Hastie et al. 2013). RasP also cleaves both of the stress response anti-sigma factors,
RsiW and RsiV, as well as the cell division protein FtsL, and remnant signal
peptides, within their transmembrane segments (Parrell et al. 2017).
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| Accession Number: | O31754 |
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| Protein Name: | Regulator of sigma-W protease RasP |
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| Length: | 422 |
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| Molecular Weight: | 46744.00 |
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| Species: | Bacillus subtilis (strain 168) [224308] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MFVNTVIAFI IIFGTLVFFH ELGHLLLAQR AGILCREFAI GFGPKIFSFK KNETVYTIRL
61: LPVGGFVRMA GEDPEMIEVK PGYTVGLLFN KEDQVEKVII NQKEKYPDAL VIEVETADLE
121: HDMKITGYEQ GKEDELSSFT VSETSFFIVD GEEVQIAPYN RQFGSKPVWQ RIKAIAAGPI
181: MNFILAYVIL VMLGLIQGVP SNEPMLGQLT DNGRAAEAGL KEGDYIQSIN GEKMRSWTDI
241: VSAVKENPEK EMDVAVKRDN KTLHISVTPE AVKDENKKTI GRFGSYAPTE KGVLSAVAYG
301: ATSTVDVTKA ILTNLSKLVT GQFKLDMLSG PVGIYDMTDQ VAKTGIVNLF QFAAFLSINL
361: GIVNLLPIPA LDGGRLLFLF IEAIRGKPIN REKEAFVVFI GVAFLMLLML VVTWNDIQRL
421: FL