9.B.149.2.3
S2P integral membrane protease, RseP (Regulator of sigmaE protease) (YaeL or EcfE), of 450 aas and 5 TMSs in a 3 (N-terminal) + 2 (C-terminal) TMS arrangement (Kanehara et al. 2002; Alba et al. 2002). RseP regulates ferric citrate uptake by cleaving the sigma factor regulator, FecR (Yokoyama et al. 2021). It can also cleave sequences in transmembrane regions
of other proteins (such as LacY) as well as liberated signal peptides
of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA,
probably within the membrane (Akiyama et al. 2004; Koide et al. 2008).
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| Accession Number: | P0AEH1 |
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| Protein Name: | Regulator of sigma-E protease RseP |
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| Length: | 450 |
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| Molecular Weight: | 49071.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein |
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1: MLSFLWDLAS FIVALGVLIT VHEFGHFWVA RRCGVRVERF SIGFGKALWR RTDKLGTEYV
61: IALIPLGGYV KMLDERAEPV VPELRHHAFN NKSVGQRAAI IAAGPVANFI FAIFAYWLVF
121: IIGVPGVRPV VGEIAANSIA AEAQIAPGTE LKAVDGIETP DWDAVRLQLV DKIGDESTTI
181: TVAPFGSDQR RDVKLDLRHW AFEPDKEDPV SSLGIRPRGP QIEPVLENVQ PNSAASKAGL
241: QAGDRIVKVD GQPLTQWVTF VMLVRDNPGK SLALEIERQG SPLSLTLIPE SKPGNGKAIG
301: FVGIEPKVIP LPDEYKVVRQ YGPFNAIVEA TDKTWQLMKL TVSMLGKLIT GDVKLNNLSG
361: PISIAKGAGM TAELGVVYYL PFLALISVNL GIINLFPLPV LDGGHLLFLA IEKIKGGPVS
421: ERVQDFCYRI GSILLVLLMG LALFNDFSRL