TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.157.1.1









The MreBCD complex which forms an essential membrane associated complex.  MreD is a 5 TMS protein resembling members of TC family with sequence similarity to the integral membrane transport protein listed under TC#  3.A.1.26.10. 

Bacteria
Bacillota
MreBCD of Bacillus subtilis
MreB, 337 aas, (Q01465)
MreC, 290 aas, (Q01466)
MreD, 172 aas, (Q01467)
9.B.157.1.2









The MreBCD complex.

Bacteria
Bacillota
MreBCD of Bacillus halodurans
MreB, 346 aas (Q9K8H5)
MreC, 293 aas (Q9K8H6)
MreD, 174 aas (Q9K8H7)  
9.B.157.1.3









Cell shape determining complex, MreBCD (347, 367 and 162 aas, respectively) (Kruse et al. 2005).  MreB is homologous to the chaperone protein Hsc70 (TC# 1.A.33.1.1) and the HscA homologues presented under TC#s 9.B.157.1.1 - 3.

Bacteria
Pseudomonadota
MreBCD of E. coli
9.B.157.1.4









MreBCD homologues

Bacteria
Spirochaetota
MreBCD homologues of Leptospira interrogans
MreB, 409 aas (Q8F2L2)
MreC, 377 aas (Q8F2L4)
MreD, 170 aas (Q8F2L5)
9.B.157.1.5









MreBCD cell shape-determining complex: Three proteins involved in Streptomyces coeicolor spore cell wall synthesis to form the thickened septum (relative to the vegegative cell wall).  MreB is 342 aas long with possibly 1 TMS at about residue 180, a second protein, MreC, which is 366 residues long with possibly 3 TMSs, one N-terminal, one at about residue 160, and one at about residue 280, and  MreD, which is 223 aas long and has 5 TMSs.  This system has been characterized (Sigle et al. 2015; Vollmer et al. 2019).  MreB gives a TC BLAST score of e-128; MreC gives a TC BLAST score of e-10, and MreD give a TC BLAST score of 0.0001 all with 9.B.157.1.4, showing that all 3 protein constituents are homology with other members of the family, but with greatly differing degrees of sequence similarities.  MreD with 5 TMSs gives a TC BLAST score of 0.0004 with T# 3.A.1.28.2, suggesting a relationship with an ABC-type membrane transport protein. 

Bacteria
Actinomycetota
MreBCD of Streptomyces coeicolor