9.B.169.1.1
9 or 10 TMS protein of 402 aas of unknown function with a C-terminal DUF418 domain and a full length YeiB domain, YxaH. The expression of its gene is regulated by two repressors, LmrA and QdoR, which also regulate the lmrAB operon which encodes LmrA as well as the multidrug resistance MFS drug exporter, LmrB (TC# 2.A.1.3.61) (Hirooka and Fujita 2011). Therefore, YxaH could be an MDR pump. Both of the two repressors bind flavonoids which cause them to dissociate from the DNA, promoting induction of gene expression, also consistent with YxaH being an MDR pump.
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| Accession Number: | P42107 |
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| Protein Name: | Uncharacterized protein YxaH |
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| Length: | 402 |
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| Molecular Weight: | 46177.00 |
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| Species: | Bacillus subtilis (strain 168) [224308] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSSLQPTLTN ERIGVLDVLR GMAIFGILFV NLAHFSYPDM YLSMLGKENF FMDKWSEADF
61: AAADILKFFI QTKCILLFSF LFGFGMVVMM ERAENKGKRF VPLYVRRLMA LLLFGTIHAF
121: LIWDGDILTE YALLGFVLLL FRKAKPKTLL IWAVSLYLLF SIPFMLTSFD QSNGQEWVQA
181: VTQQAKQAIH VYGSGSLKDI AEQRIHDRLV YMSSNGMLTY NPLNYFFASI PYFSMFLLGA
241: AAAKSRYLHE PEKHRKGLKR LWMAGLVIGI GAQVLYSVTD KEICLLIGAP FLMFFYVTTV
301: VYLYHKTRVR TVLQSFSAVG RMAFTNYLMQ SIVCTWIFYH YGLGLYGKVY PAAGVLITIA
361: VCAVQMVFSH LWLRVFRMGP FEWLWRSATY LSWQPIAKKT KV