9.B.17.2.1
Sec14-like protein1, Sec14L1 of 715 aas and 0 TMSs. It may play a role in innate immunity by inhibiting the antiviral RIG-I
signaling pathway. In this pathway, it functions as a negative regulator of
DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. It prevents
the interaction of DDX58 with MAVS/IPS1, an important step in signal
propagation (Li et al. 2013). It may also regulate the SLC18A3 and SLC5A7 cholinergic transporters (Ribeiro et al. 2007). It contains a Golgi Dynamics (GOLD) domain (Mendes and Costa-Filho 2022).
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| Accession Number: | Q92503 |
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| Protein Name: | SEC14-like protein 1 |
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| Length: | 715 |
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| Molecular Weight: | 81250.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK
61: LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN
121: EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR
181: WSPPSITTSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD
241: ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ
301: SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE
361: EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLWRPG VKALLRIIEV
421: VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK
481: EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI
541: QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ
601: LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ
661: VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISR