TCDB is operated by the Saier Lab Bioinformatics Group

9.B.18 The Xanthan Glycosyl Transferase, GumD (GumD) Family

The GumD family cosists of a large number of glycosyltransferases involved in exo-polysaccharide biosynthesis and export.  GumD of Xanthomonas campestris is a costituent of a multicomponent system involved in the biosynthesis and export to the cell surface.  Some of the constituents of this system include GumB (TC# 1.B.18.3.7) and GumC (TC#8.A.3.1.3) (Bianco et al. 2014).  The N-terminus of GumD (residues 30 - 140) consists of a domain of closely packed 4 TMSs, followed by a hydrophilic domain that includes 1 or 2 additional TMSs.  Residues 75 - 275 consist of the NADB_Rossmann or CoA binding_3 domain, while residues 300 to the end consist of the Bacterial Transferase (bac_transf) domain of CDD. 

References associated with 9.B.18 family:

Bianco, M.I., M. Jacobs, S.R. Salinas, A.G. Salvay, M.V. Ielmini, and L. Ielpi. (2014). Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris. Protein Expr Purif 101: 42-53. 24927643
Hegeman, A.D., J.W. Gross, and P.A. Frey. (2001). Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site. Biochemistry 40: 6598-6610. 11380254
Pérez-Burgos, M., I. García-Romero, J. Jung, E. Schander, M.A. Valvano, and L. Søgaard-Andersen. (2020). Characterization of the Exopolysaccharide Biosynthesis Pathway in Myxococcus xanthus. J. Bacteriol. 202:. 32778557
Yang, J., J. Zhang, Z. Zhu, X. Jiang, T. Zheng, and G. Du. (2022). Revealing novel synergistic defense and acid tolerant performance of Escherichia coli in response to organic acid stimulation. Appl. Microbiol. Biotechnol. [Epub: Ahead of Print] 36326840