9.B.188.1.2
The transmembrane (2 TMSs, N- and C-termini) Emp24 domain-containing protein 2, TMED2 or RNP24 of 201 aas. A role for TMED2 in liver health has been suggested (Hou et al. 2017). The structure, topology, and dynamics of membrane-inserted polypeptides and lipids have been examined by solid-state NMR spectroscopy, specifically with respect to the transmembrane domains of the DQ Beta-1 subunit of the MHC II receptor and the COP I protein, p24 (Salnikov et al. 2019). The role of the p24/transmembrane emp24 domain (TMED) family of cargo receptors in development and disease has been reviewed (Aber et al. 2019). TMED2/emp24 is required in both the chorion and the allantois for placental labyrinth layer development involving membrane fusion (Hou and Jerome-Majewska 2018). Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR-186 and inducing TMED2 (Zhang et al. 2022). TMED2 induces cisplatin resistance in breast cancer by targeting the KEAP1-Nrf2 pathway (Liang et al. 2023).