9.B.191.1.10
ER lumen protein-retaining receptor, Erd-2.1, ERD-2.1 or Erd2.1, of 213 aas and 7 TMSs. It is required for the retention of luminal endoplasmic
reticulum proteins and determines the specificity of the system. it is also required for normal vesicular trafficing through the Golgi. It is 67% identical to the human receptor with TC# 9.B.191.1.5. It catalyzes COPI-dependent Golgi-to-ER retrograde traffic. There seems to be an interaction between the vesicular acetylcholine transporter and ERD2 receptor.
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| Accession Number: | P48583 |
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| Protein Name: | ER lumen protein-retaining receptor erd-2.1 |
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| Length: | 213 |
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| Molecular Weight: | 25060.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein |
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1: MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD LFTNFFSFYN
61: TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI PSMILALLIN HEFIFMEVMW
121: TFSIYLEAVA IMPQLFMLSR TGNAETITAH YLFALGSYRF LYILNWVYRY YTESFFDPIS
181: VVAGIVQTVL YADFFYLYIT RVIQSNRQFE MSA