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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
9.B.2.1.1	CAAX protease2 of 302aas and 8 TMSs	Bacteria	Chlamydiota	CAAX protease2 of Parachlamydia acanthamoebae (F8KZQ2)
9.B.2.1.2	CAAX protease2 of 258aas and 7 or 8 TMSs.	Bacteria	Chlamydiota	CAAX protease2 of Chlamydophila pecorum (F4DIL5)
9.B.2.1.3	CAAX protease2 of 256aas and 7 or 8 TMSs	Bacteria	Chlamydiota	CAAX protease of Chlamydia trachomatis (Q3KMA8)
9.B.2.1.4	Uncharacterized protein of 420 aas	Archaea	Euryarchaeota	UP of Methanothermobacter thermautotrophicus
9.B.2.1.5	CAAX protease2 of 239aas and 5 or 6 TMSs	Bacteria	Bacteroidota	CAAX protease2 of Porphyromonas catoniae (L1NER1)
9.B.2.1.6	Me²⁺-dependent protease of 303aas and 8 TMSs	Bacteria	Cyanobacteriota	Protease of Acaryochloris marina (B0C1B4)
9.B.2.1.7	CAAX protease2 of 373aas and 11 TMSs	Archaea	Euryarchaeota	CAAX protease2 of Natronolimnobius innermongolicus (L9XEM0)
9.B.2.1.8	CAAX protease2 of 230aas and 6 TMSs	Bacteria	Bacillota	CAAX protease2 of Sporosarcina newyorkensis (F9DWD5)
9.B.2.1.9	MceF CAAX Protease	Bacteria	Pseudomonadota	MceF of Klebsiella pneumoniae
9.B.2.1.10	CAAX protease involved in immunity against bacteriocins (Pei and Grishin 2001).	Bacteria	Bacillota	CAAX protease of Streptococcus pyogenes
9.B.2.1.11	CAAX protease of 233 aas.	Eukaryota		CAAX protease of Guillardia theta
9.B.2.1.12	Abortive infection domain protein, Abi of 193 aas. The C-terminal region has the Abi domain.	Bacteria	Pseudomonadota	Putative CAAX protease of Marinobacter aquaeolei (Marinobacter hydrocarbonoclasticus)
9.B.2.1.13	Abortive infection-like protein of 323 aas with a C-terminal Abi domain.	Eukaryota	Rhodophyta	Abi protein of Galdieria sulphuraria
9.B.2.1.14	Abi domain-containing protein of 305 aas and 10 TMSs.	Bacteria	Acidobacteriota	Abi protein of Koribacter versatilis
9.B.2.1.15	Abi domain-containing protein of 400 aas and 10 TMSs.	Eukaryota	Rhodophyta	Abi protein of Galdieria sufphuraria
9.B.2.1.16	LsrS, a 229 aas CAAX peptidase that is required for receptor function for the killing activity of the lantibiiotics Smb and nisin (Biswas and Biswas 2014). The peptidase activity is not required for receptor function.	Bacteria	Bacillota	LsrS of Streptococcus mutans
9.B.2.1.17	CAAX protease of 223 aas and 7 TMSs	Eukaryota	Viridiplantae, Chlorophyta	CAAX protease of Chlamydomonas reinhardtii
9.B.2.1.18	Putative CAAX protease of 215 aas and 6 TMSs	Bacteria	Bacillota	CAAX protease of Lactobacillus rhamnosus
9.B.2.1.19	Membrane peptidase, YdiL, of 293 aas.	Eukaryota	Viridiplantae, Streptophyta	YdiL of Capsicum annuum
9.B.2.1.20	Intramembrane metaloprotease of 195 aas and 7 TMSs.	Bacteria	Bacillota	Protease of Lactobacillus xiangfangensis
9.B.2.1.21	CPBP protease family member of 225 aas and 6 TMSs.	Bacteria	Bacillota	Protease of Bacillus cereus
9.B.2.1.22	CPBP integral membrane metaloprotease (sortase?) family member of 242 aas and 6 or 7 TMSs.	Bacteria	Pseudomonadota	Protease of Dokdonella koreensis
9.B.2.1.23	CAAX amino terminal protease family protein of 351 aas and 8 TMSs.	Bacteria	Bacillota	CAAX protease of Clostridium methylpentosum
9.B.2.1.24	Uncharacterized putative integral membrane proteinof 240 aas and 6 TMSs.	Bacteria	Actinomycetota	UP of Mycobacterium tuberculosis
9.B.2.1.25	CAAX protease of 357 aas and 7 TMSs.	Archaea	Candidatus Lokiarchaeota	CAAX protease of Lokiarchaeum sp.
9.B.2.1.26	Uncharacterized putative peptidase of 163 aas and 5 putative TMSs.	Archaea	Candidatus Thorarchaeota	UP of Candidatus Thorarchaeota archaeon AB_25 (marine sediment metagenome)
9.B.2.1.27	Uncharacterized protein of 325 aas and 8 TMSs	Archaea	Candidatus Thorarchaeota	UP of Candidatus Thorarchaeota archaeon AB_25 (marine sedimet metagenome)
9.B.2.1.28	CPBP family intramembrane metalloprotease of 1141 aas and 7 TMSs, all at the C-terminus of the protein.	Bacteria	Actinomycetota	Protease of Bifidobacterium indicum
9.B.2.1.29	JDVT-CTERM system glutamic-type intramembrane protease of 163 aas and 5 TMSs. It may not be full length.	Bacteria	Pseudomonadota	Protease of Noviherbaspirillum sp.
9.B.2.2.1	CAAX protease of 274 aas	Eukaryota	Rhodophyta	CAAX protease of Galdieria sulphuraria
9.B.2.3.1	CAAX amino terminal protease of 306 aas and 8 TMSs.	Bacteria	Bacillota	CAAX protease of Desulfitobacterium metallireducens
9.B.2.3.2	CAAX protease of 274 aas and 8 TMSs.	Bacteria	Chloroflexota	CAAX protease of Anaerolnea thermopila
9.B.2.4.1	Putative transporter of 206 aas and 6 TMSs.	Bacteria	Pseudomonadota	Putative transporter of Klebsiella pneumoniae
9.B.2.4.2	Uncharacterized protein of 217 aas and 6 TMSs.	Bacteria	Pseudomonadota	UP of Vibrio fischeri
9.B.2.4.3	Putative Brp/Blh family of β-carotene monooxygenases of 221 aas and 6 TMSs	Bacteria	Bacteroidota	UP of Psychroflexus torquis
9.B.2.5.1	Uncharacterized protein of 230 aas and 6 TMSs	Bacteria	Pseudomonadota	UP of Deftia acidovorans
9.B.2.5.2	Uncharacterized protein of 206 aas and 6 TMSs	Bacteria	Bacillota	UP of Acidaminococcus intestini
9.B.2.5.3	Uncharacterized protein of 215 aas and 6 TMSs	Bacteria	Pseudomonadota	UP of Salmonella schwarzengrund
9.B.2.5.4	Uncharacterized protein of 215 aas and 6 TMSs	Bacteria	Bacillota	UP of Megamonas hypermegale
9.B.2.6.1	Uncharacterized protein of 209 aas and 5 or 6 TMSs	Bacteria	Thermodesulfobacteriota	UP of Geobacter sp.
9.B.2.6.2	Uncharacterized protein of 181 aas and 5 putative TMSs.	Bacteria	Thermodesulfobacteriota	UP of an uncultured Desulfobacterium
9.B.2.6.3	Uncharacterized protein of 228 aas and 6 TMSs	Bacteria	Pseudomonadota	UP of Parvibaculum lavamentivorans
9.B.2.6.4	Uncharacterized protein of 181 aas and 5 TMSs.	Bacteria	Pseudomonadota	UP of Thioalkalimicrobium cyclicum
9.B.2.6.5	Uncharacterized protein of 228 aas and 7 TMSs	Bacteria	Pseudomonadota	UP of Phyllobacterium sp. YR531
9.B.2.6.6	Uncharacterized protein of 172 aas and 5 TMSs.	Archaea	Euryarchaeota	UP of Methanococcus maripaludis
9.B.2.6.7	Uncharacterized protein of 227 aas and 6 TMSs	Bacteria	Pseudomonadota	UP of Rhizobium sp.
9.B.2.7.1	Uncharacterized protein of 213 aas and 6 TMSs. This protein is the only member of its subfamily, but a protein from Zymophilus raffinosivorans (gi# 518382944), not in UniProt as of 5/5/14, shows similarity to it as well as members of subfamily 9.B.2.5.	Bacteria	Pseudomonadota	UP of Octadecabacter antarcticus
9.B.2.8.1	Putative CPBP family membrane metaloprotease of 195 aas and 7 TMSs.	Bacteria	Bacillota	Protease of Streptococcus ferus
9.B.2.8.2	Putative membrane metaloprotease of 193 aas and 6 TMSs.	Bacteria	Candidatus Saccharibacteria	Protease of Candidatus Saccharibacteria bacterium
9.B.2.9.1	Uncharacterized protein of 329 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement	Archaea	Euryarchaeota	UP of Natronorubrum tibetense
9.B.2.10.1	The CPBP family intramembrane metalloprotease domain-containing protein of 468 aas and 7 TMSs.	Archaea	Candidatus Thermoplasmatota	CPBP protease of Methanomassiliicoccus luminyensis
9.B.2.10.2	Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 366 aas and 8 TMSs.	Archaea	Candidatus Thermoplasmatota	UP of Aciduliprofundum boonei
9.B.2.10.3	Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 369 aas and 7 TMSs.	Archaea	Candidatus Thermoplasmatota	UP of Candidatus Methanomethylophilus alvus
9.B.2.10.4	Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 301 aas and 7 TMSs.	Archaea	Candidatus Thermoplasmatota	UP of methanogenic archaeon ISO4-H5
9.B.2.10.5	Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 312 aas and 7 TMSs.	Archaea	Nitrososphaerota	UP of Candidatus Nitrosopelagicus brevis
9.B.2.11.1	CPBP family intramembrane metalloprotease of 213 aas	Bacteria	Pseudomonadota	Protease of Pseudoalteromonas
9.B.2.11.2	CPBP/CAAX family intramembrane metaloprotease of 221 aas and 6 TMSs.	Bacteria	Pseudomonadota	Metaloprotease of Microbulbifer aggregans
9.B.2.11.3	CAAX amino terminal protease self-immunity of 194 aas and 6 TMSs in a 2 + 2 + 2 arrangement.	Archaea	Candidatus Lokiarchaeota	CAAX protease of Lokiarchaeum sp. GC14_75 (marine sediment metagenome)
9.B.2.12.1	Uncharacterized protein of 207 aas and 6 TMSs	Bacteria	Candidatus Peregrinibacteria	UP of Candidatus Peribacter riflensis
9.B.2.12.2	Metaloprotease of 213 aas and 6 TMSs	Bacteria	Bacteroidota	Metaloprotease of Lewinella cohaerens
9.B.2.13.1	Putative CAAX protease of 496 aas and 7 TMSs in a 1 (N-terminal) + 6 (C-terminal) TMS arrangement. The gene for this protein is adjacent to an ABC transporter (TC# 3.A.1.128.10), probably specific for a sporulation killing factor, SkfB (Grell et al. 2018). This protease may therefore function to process SkfB.	Bacteria	Bacillota	Protease of Bacillus stratosphericus
9.B.2.14.1	Myxosortase X, MXAN-2755 or MrtX of 239 aas with 4 to 6 TMSs in a possibly 2 + 1 + 2 + 1 arrangement. It is a CPBP family intramembrane metalloprotease. Other myxosortases include: MrtC (TC# 9.B.2.14.2), MrtP (TC# 9.B.2.14.3), MrtJ, MrtS and MrtA. All of these systems are present in Myxococcus xanthus (Haft 2024).	Bacteria	Myxococcota	MrtX of Myxococcus xanthus
9.B.2.14.2	MrtC sortase; glutamic-type intramembrane protease of 247 aas and 6 TMSs.	Bacteria	Myxococcota	MrtC of Polyangiaceae bacterium
9.B.2.14.3	Myxosortase MrtP OF 361 aas and 7 putative TMSs in a 3 (N-terminal) + 4 (C-terminal) TMS arrangement.	Bacteria		MrtP of Lujinxingia vulgaris