9.B.20.1.1
Putative Mg2+ transporter, MgtC (Retamal et al. 2009). The MgtC virulence protein binds to the F-type ATP synthase and maintains ATP homeostasis required for pathogenesis during phagosome acidification (Lee and Lee 2015). The mgtC gene, which is present in S. enterica but not in E. coli,
is responsible for the differences in RpoS accumulation between these
two bacterial species. Thus, bacteria possess a
mechanism to control RpoS accumulation responding to cytoplasmic Mg2+ levels, the difference of which causes distinct RpoS accumulation patterns in closely related bacterial species (Park et al. 2018).
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| Accession Number: | P22037 |
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| Protein Name: | ATMC aka MgtC aka STM3764 |
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| Length: | 231 |
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| Molecular Weight: | 25065.00 |
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| Species: | Salmonella typhimurium [90371] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
magnesium(2+) |
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| RefSeq: |
NP_462663.1
|
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| Entrez Gene ID: |
1255288
|
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| Pfam: |
PF02308
|
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| BioCyc: |
STYP99287:STM3764-MONOMER
|
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| KEGG: |
stm:STM3764
|
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[1] “The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase.” Snavely M.D. et.al. 1824701
[2] “The SPI-3 pathogenicity island of salmonella enterica.” Blanc-Potard A.-B. et.al. 9922266
[3] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M. et.al. 11677609
[4] “The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival.” Blanc-Potard A.-B. et.al. 9311997
[5] “Magnesium and the role of MgtC in growth of Salmonella typhimurium.” Moncrief M.B.C. et.al. 9673265
[6] “The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase.” Guenzel D. et.al. 16855249
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1: MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD
61: SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI
121: IILCANILLR EAAQRINQLP ISAEGEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG
181: LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWSIDS Q