9.B.208.1.7
Oxysterol receptor, LXR-allpha (LXRα) of 447 aas and 0 - 2 TMSs. The effect of liver X receptor agonist TO901317 on cognitive function in APP/PS1 double transgenic mice with Alzheimer's disease and the underlying mechanism have been determined (Luo et al. 2022). Soyasapogenol C is a liver X receptor α agonist that mitigates cholesterol accumulation in diabetic kidney disease (Zhang et al. 2025).
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| Accession Number: | Q13133 |
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| Protein Name: | Oxysterols receptor LXR-alpha |
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| Length: | 447 |
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| Molecular Weight: | 50396.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
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| Substrate |
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1: MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA
61: AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV CGDKASGFHY NVLSCEGCKG
121: FFRRSVIKGA HYICHSGGHC PMDTYMRRKC QECRLRKCRQ AGMREECVLS EEQIRLKKLK
181: RQEEEQAHAT SLPPRASSPP QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM
241: APDPHSREAR QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL
301: ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ LNDAEFALLI
361: AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD RLMFPRMLMK LVSLRTLSSV
421: HSEQVFALRL QDKKLPPLLS EIWDVHE