9.B.213.1.2
The PalH pH sensor of 760 aas and 7 TMSs (Peñalva et al. 2014) PalH mechanistically resembles mammalian GPCRs that signal via arrestins (Lucena-Agell et al. 2016). PalH is involved in developmental competence - the capacity to respond to induction of asexual development (Noble et al. 2016).
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| Accession Number: | Q9P904 |
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| Protein Name: | pH-response regulator protein palH/RIM21 |
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| Length: | 760 |
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| Molecular Weight: | 83657.00 |
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| Species: | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) [227321] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEDDGRLAPR QIWARPTSTT TRSYVPGCTP FLLPSDGYVY LNRTYSISLG ENAIYDPACT
61: STPTTTEHAG AALDIHDPFY ASVTPLLYAM GCATVVSYLL VIILLITPRT FYVGGPGGGA
121: NFLGRHGMVS GSYSNNSSVV GVGGRPWLQK VAALLVAISL TIATADSFRV AEKQYDHGYS
181: DAEALTSEVI DGTEIKVVRI ISSTFLWLAQ VQTLIRLFPR HKEKVMIKWA GFALIVLDTI
241: FAILDKFLVK TNTTRPRLYE DAIPALSYLF ELALNLLYAA WVIFYSLSKH RFAFFHPKMR
301: NICLVALLSL CAVLIPVVFF VLDIAKPEIA GWGTYIRWVG SAAASVVVWE WVERIEALER
361: DERKDGILGR EVFDGDEMIE VTPSEEVDWP RQQFHGHDRG GGTGMSSAWG GVMGLAHRPL
421: RPRGGRITQT QREAEGATAA KSRKRRSARP TPPPAAVTPV SRADTTSAAS TVYNVHYYPV
481: SSPTPPVAMP FMEEEDEGSD GDGEKELAVV QNQQSSLPTQ DTYTEPRRQN SPQIVNVDNR
541: WRFILNPFKN RHAALPREVA SAQAEEEGFL SPDDQAPRQG DEENPHYTPR HRGLFSFHPM
601: SDGASRRQSG ADQPLPVTVI PARRRGQDTW SPQWFTNSNL VDRSSSRRTA SRPRDQRMKV
661: IQPQVQSAAP WTAADMEASF SSMDYELRYD PEAAALVSED IPDHHSQPTQ ADSPAHPTMS
721: GGNGPSGGET QSALDTGPGI EGSVNEGSVI EGPEESHSQR